Stereoselective synthesis of the hydroxyethylene isostere of the HIV protease (Tyr-Pro) cleavage site

Stereoselective synthesis of the hydroxyethylene isostere of the HIV protease (Tyr-Pro) cleavage site

The stereoselective, syntheses and IC 50's of Tyr-HE-Pro based inhibitors are reported. The [2S,3S,4S,5S]-stereochemistry was preferred by HIV-1 protease. The stereoselective syntheses and IC 50's of Tyr-HE-Pro based inhibitors ( 15) via intramolecular epoxide alkylation of 10 are reported...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 1992-05, Vol.33 (21), p.2957-2960
Hauptverfasser: Thompson, Wayne J., Ball, Richard G., Darke, Paul L., Zugay, Joan A., Thies, J.E.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Exact sciences and technology
Noncondensed benzenic compounds
Organic chemistry
Physical Sciences
Preparations and properties
Science & Technology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The stereoselective, syntheses and IC 50's of Tyr-HE-Pro based inhibitors are reported. The [2S,3S,4S,5S]-stereochemistry was preferred by HIV-1 protease. The stereoselective syntheses and IC 50's of Tyr-HE-Pro based inhibitors ( 15) via intramolecular epoxide alkylation of 10 are reported.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)79571-2