Cytokines as immunological adjuvants
Various cytokines have been shown to be effective immunological adjuvants in a variety of model systems, enhancing protection induced by viral, bacterial and parasitic vaccines, and increasing parameters of immunity in tumour immunization models and in clinical trials. While in most cases cytokine a...
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| Veröffentlicht in: | Vaccine 1992, Vol.10 (7), p.427-434 |
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| container_end_page | 434 |
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| container_issue | 7 |
| container_start_page | 427 |
| container_title | Vaccine |
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| creator | Heath, A.W. Playfair, J.H.L. |
| description | Various cytokines have been shown to be effective immunological adjuvants in a variety of model systems, enhancing protection induced by viral, bacterial and parasitic vaccines, and increasing parameters of immunity in tumour immunization models and in clinical trials. While in most cases cytokine adjuvanticity is not as powerful as that shown by the best experimental adjuvants, such as saponin and Freund's, it can rival that of the adjuvants presently allowed for human use and there are many possible routes to improvement. The use of cytokines may allow for a choice of which immune parameters are enhanced in order to further enhance protective effects and decrease the negative effects of vaccines. |
| doi_str_mv | 10.1016/0264-410X(92)90389-2 |
| format | Article |
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While in most cases cytokine adjuvanticity is not as powerful as that shown by the best experimental adjuvants, such as saponin and Freund's, it can rival that of the adjuvants presently allowed for human use and there are many possible routes to improvement. The use of cytokines may allow for a choice of which immune parameters are enhanced in order to further enhance protective effects and decrease the negative effects of vaccines.</description><subject>adjuvant</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytokines</subject><subject>Cytokines - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>immunodeficiency</subject><subject>Immunology</subject><subject>interferon gamma</subject><subject>Interferon-gamma - pharmacology</subject><subject>interleukin 1</subject><subject>interleukin 2</subject><subject>Interleukin-1 - pharmacology</subject><subject>Interleukin-2 - pharmacology</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine, Research & Experimental</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Research & Experimental Medicine</subject><subject>Science & Technology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkd9L5DAQx4Mouqf-Bwr7IHLHUZ1Mk7Z5EaTcnQfCvaj4FrL5IdG20aZd8b-_rF323k6fMjCf75D5DCFHFM4o0OIcsGAZo3D_VeA3AXklMtwiM1qVeYacVttktkH2yJcYHwGA51Tskl1agOCMz8hJ_TaEJ9_ZOFdx7tt27EITHrxWzVyZx3GpuiEekB2nmmgP1-8-uf3546a-yq7__PpdX15nmtFyyEoAp5QzFVbpD5zpsjR04RioAnPF0GjghTaMO4Yld44yjiXqVC7QgDX5Pjmd5j734WW0cZCtj9o2jepsGKMs87QAsuJDkBY5zTmsQDaBug8x9tbJ5963qn-TFOTKolwpkitFUqB8tygxxY7X88dFa82_0KQt9U_WfRWTKderTvu4wTiKAgVL2PcJe7WL4KL2ttN2Q11SIfDqrqpYugvQRFefp2s_qMGHrg5jN6ToxRS16TpLb3u5jhvfWz1IE_z_F_4LDyitnA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Heath, A.W.</creator><creator>Playfair, J.H.L.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Cytokines as immunological adjuvants</title><author>Heath, A.W. ; Playfair, J.H.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-700faafd82887354c77d1bf40a623a42dc056cd45f4275ff145272c75fb2d0ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>adjuvant</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cytokines</topic><topic>Cytokines - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>immunodeficiency</topic><topic>Immunology</topic><topic>interferon gamma</topic><topic>Interferon-gamma - pharmacology</topic><topic>interleukin 1</topic><topic>interleukin 2</topic><topic>Interleukin-1 - pharmacology</topic><topic>Interleukin-2 - pharmacology</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine, Research & Experimental</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Research & Experimental Medicine</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heath, A.W.</creatorcontrib><creatorcontrib>Playfair, J.H.L.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heath, A.W.</au><au>Playfair, J.H.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokines as immunological adjuvants</atitle><jtitle>Vaccine</jtitle><stitle>VACCINE</stitle><addtitle>Vaccine</addtitle><date>1992</date><risdate>1992</risdate><volume>10</volume><issue>7</issue><spage>427</spage><epage>434</epage><pages>427-434</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Various cytokines have been shown to be effective immunological adjuvants in a variety of model systems, enhancing protection induced by viral, bacterial and parasitic vaccines, and increasing parameters of immunity in tumour immunization models and in clinical trials. While in most cases cytokine adjuvanticity is not as powerful as that shown by the best experimental adjuvants, such as saponin and Freund's, it can rival that of the adjuvants presently allowed for human use and there are many possible routes to improvement. The use of cytokines may allow for a choice of which immune parameters are enhanced in order to further enhance protective effects and decrease the negative effects of vaccines.</abstract><cop>OXFORD</cop><pub>Elsevier Ltd</pub><pmid>1609545</pmid><doi>10.1016/0264-410X(92)90389-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Vaccine, 1992, Vol.10 (7), p.427-434 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | adjuvant Adjuvants, Immunologic - pharmacology Animals Biological and medical sciences Cytokines Cytokines - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology immunodeficiency Immunology interferon gamma Interferon-gamma - pharmacology interleukin 1 interleukin 2 Interleukin-1 - pharmacology Interleukin-2 - pharmacology Life Sciences & Biomedicine Medicine, Research & Experimental Modulation of the immune response (stimulation, suppression) Research & Experimental Medicine Science & Technology |
| title | Cytokines as immunological adjuvants |
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