THE MULTIFUNCTIONAL FOLIC-ACID SYNTHESIS FAS GENE OF PNEUMOCYSTIS-CARINII APPEARS TO ENCODE DIHYDROPTEROATE SYNTHASE AND HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE
We describe the cloning of a multifunctional folic acid synthesis (fas) gene from Pneumocystis carinii. The nucleotide sequence contains an open reading frame interrupted by three introns, that encodes a protein of 740 amino acids with an M(r) of 97 278. The predicted Fas protein has homology to two...
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| Veröffentlicht in: | Gene 1992-03, Vol.112 (2), p.213-218 |
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| container_title | Gene |
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| creator | VOLPE, F DYER, M SCAIFE, JG DARBY, G STAMMERS, DK DELVES, CJ |
| description | We describe the cloning of a multifunctional folic acid synthesis (fas) gene from Pneumocystis carinii. The nucleotide sequence contains an open reading frame interrupted by three introns, that encodes a protein of 740 amino acids with an M(r) of 97 278. The predicted Fas protein has homology to two enzyme domains, dihydropteroate synthase and 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, both of which are involved in folate synthesis, and at least one other region of unknown function. |
| doi_str_mv | 10.1016/0378-1119(92)90378-3 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0378-1119 |
| ispartof | Gene, 1992-03, Vol.112 (2), p.213-218 |
| issn | 0378-1119 |
| language | eng |
| recordid | cdi_webofscience_primary_A1992HM54400009CitationCount |
| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Base Sequence Cloning, Molecular Dihydropteroate Synthase - genetics Diphosphotransferases Folic Acid - biosynthesis Genes, Fungal - genetics Genetics & Heredity Life Sciences & Biomedicine Molecular Sequence Data Phosphotransferases - genetics Pneumocystis - enzymology Pneumocystis - genetics Science & Technology |
| title | THE MULTIFUNCTIONAL FOLIC-ACID SYNTHESIS FAS GENE OF PNEUMOCYSTIS-CARINII APPEARS TO ENCODE DIHYDROPTEROATE SYNTHASE AND HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE |
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