Valproate Use Associated with Persistent Hyperammonemia and Mitochondrial Injury in a Child with Downʼs Syndrome

Valproate is a commonly prescribed anticonvulsant drug that may cause potentially fatal hepatotoxicity, bone-marrow toxicity, and pancreatitis. Toxicity usually resolves, though, after discontinuation of the medication. We report a 9-year-old boy who had Downʼs syndrome and who developed valproate-a...

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