Membrane Trapping of Carbon-11-Labeled 1,2-Diacylglycerols as a Basic Concept for Assessing Phosphatidylinositol Turnover in Neurotransmission Process

The uptake mechanism of 1,2-[C-11]diacylglycerols (DAG) was studied and its use as a probe for the measurement of phosphatidylinositol (Pl) turnover was verified. A method of synthesis for producing rac-1,2-[C-11]DAG using [C-11]ethylketene was developed to label the 1- or 3-hydroxyl group of 2-mono...

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