Electron microscopy at 1-Å resolution by entropy maximization and likelihood ranking

The resolution of electron microscopy may be extended by combining the phase information in microscope images with electron diffraction intensities. A general method for obtaining structural reconstructions at a resolution greater than that of the phase information is demonstrated for crystals of perchlorocoronene. By using entropy maximization methods combined with likelihood ranking, the resolution is extended from 0.32 nm in the microscope images to 0.1 nm in the reconstruction from phase and intensity data.