Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequenc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of virology 1992-01, Vol.122 (3-4), p.399-409
Hauptverfasser:	TRACY, S, CHAPMAN, N. M, TU, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Coxsackievirus Infections - microbiology DNA, Viral Enterovirus B, Human - genetics Enterovirus B, Human - pathogenicity Fundamental and applied biological sciences. Psychology Genome, Viral Heart Diseases - microbiology HeLa Cells Humans Male Mice Mice, Inbred C3H Microbiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Virology Virulence - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/BF01317202