Molecular heterogeneity of human IgA antibodies during an immune response
SUMMARY Human IgA occurs in multiple molecular forms (polymeric and monomeric) and two subclasses which show differential distribution between the mucosal and circulatory compartments of the immune system. However, the molecular form and subclass of specific IgA antibodies are influenced, especially...
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| Veröffentlicht in: | Clinical and experimental immunology 1992-01, Vol.87 (1), p.1-6 |
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| container_title | Clinical and experimental immunology |
| container_volume | 87 |
| creator | RUSSELL, M. W. LUE, C. WALL BAKE, A. W. L. MOLDOVEANU, Z. MESTECKY, J. |
| description | SUMMARY
Human IgA occurs in multiple molecular forms (polymeric and monomeric) and two subclasses which show differential distribution between the mucosal and circulatory compartments of the immune system. However, the molecular form and subclass of specific IgA antibodies are influenced, especially during an immune response, by the type of antigen and duration of the response as well as by the route of exposure. These considerations question previously held notions that polymeric IgA and an increased representation of the IgA2 subclass among circulating antibodies or antibody‐secreting cells signify their mucosal origin. Although the functional properties of different molecular forms and subclasses of IgA antibodies are incompletely understood, it appears that there is physiological benefit in the diversity of the IgA immune system. |
| doi_str_mv | 10.1111/j.1365-2249.1992.tb06404.x |
| format | Article |
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Human IgA occurs in multiple molecular forms (polymeric and monomeric) and two subclasses which show differential distribution between the mucosal and circulatory compartments of the immune system. However, the molecular form and subclass of specific IgA antibodies are influenced, especially during an immune response, by the type of antigen and duration of the response as well as by the route of exposure. These considerations question previously held notions that polymeric IgA and an increased representation of the IgA2 subclass among circulating antibodies or antibody‐secreting cells signify their mucosal origin. Although the functional properties of different molecular forms and subclasses of IgA antibodies are incompletely understood, it appears that there is physiological benefit in the diversity of the IgA immune system.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/j.1365-2249.1992.tb06404.x</identifier><identifier>PMID: 1733625</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Antibodies, immunoglobulins ; Antibody Formation ; antibody responses ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; IgA subclasses ; Immunoglobulin A - analysis ; Immunoglobulin A - classification ; Immunoglobulin A - physiology ; Immunology ; Life Sciences & Biomedicine ; Molecular immunology ; polymeric/monomeric IgA ; Science & Technology ; Structure</subject><ispartof>Clinical and experimental immunology, 1992-01, Vol.87 (1), p.1-6</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>67</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992GY83300001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c5341-846c93b39ac66f8da0d040d66521bd3013c66391b7686ee3a9e9e17ceaf98fcc3</citedby><cites>FETCH-LOGICAL-c5341-846c93b39ac66f8da0d040d66521bd3013c66391b7686ee3a9e9e17ceaf98fcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1554245/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1554245/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,27201,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5088313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1733625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RUSSELL, M. W.</creatorcontrib><creatorcontrib>LUE, C.</creatorcontrib><creatorcontrib>WALL BAKE, A. W. L.</creatorcontrib><creatorcontrib>MOLDOVEANU, Z.</creatorcontrib><creatorcontrib>MESTECKY, J.</creatorcontrib><title>Molecular heterogeneity of human IgA antibodies during an immune response</title><title>Clinical and experimental immunology</title><addtitle>CLIN EXP IMMUNOL</addtitle><addtitle>Clin Exp Immunol</addtitle><description>SUMMARY
Human IgA occurs in multiple molecular forms (polymeric and monomeric) and two subclasses which show differential distribution between the mucosal and circulatory compartments of the immune system. However, the molecular form and subclass of specific IgA antibodies are influenced, especially during an immune response, by the type of antigen and duration of the response as well as by the route of exposure. These considerations question previously held notions that polymeric IgA and an increased representation of the IgA2 subclass among circulating antibodies or antibody‐secreting cells signify their mucosal origin. Although the functional properties of different molecular forms and subclasses of IgA antibodies are incompletely understood, it appears that there is physiological benefit in the diversity of the IgA immune system.</description><subject>Animals</subject><subject>Antibodies, immunoglobulins</subject><subject>Antibody Formation</subject><subject>antibody responses</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>IgA subclasses</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin A - classification</subject><subject>Immunoglobulin A - physiology</subject><subject>Immunology</subject><subject>Life Sciences & Biomedicine</subject><subject>Molecular immunology</subject><subject>polymeric/monomeric IgA</subject><subject>Science & Technology</subject><subject>Structure</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqVUtGK1DAUDaKss6ufIBQRX5bWpGnTRBZhKOs6sOKLPvgU0vR2JkObjEmrO39vypRRn9S8hNxzzr3ncoLQS4IzEs-bfUYoK9M8L0RGhMizscGswEX28AitztBjtMIYi1QQXDxFlyHs45Mxll-gC1JRyvJyhTYfXQ966pVPdjCCd1uwYMZj4rpkNw3KJpvtOlF2NI1rDYSknbyx21hJzDBMFhIP4eBsgGfoSaf6AM-X-wp9eX_7uf6Q3n-629Tr-1SXtCApL5gWtKFCacY63irc4gK3jJU5aVqKCY11KkhTMc4AqBIggFQaVCd4pzW9Qu9OfQ9TM0CrwY5e9fLgzaD8UTpl5J-INTu5dd8lKcsiL8rY4PXSwLtvE4RRDiZo6HtlwU1BVnklcs7pX4mEUc5LQiLx7YmovQvBQ3d2Q7CcE5N7Occi51jknJhcEpMPUfzi931-SU8RRfzVgqugVd95ZbUJZ1qJo1Uym70-0X5A47qgDVgNZ9Z6Hnr3NS4V_wCeHfN_Z9dmVKNxtnaTHaP0ZpGaHo7_samsbzeE_gQhjNTo</recordid><startdate>199201</startdate><enddate>199201</enddate><creator>RUSSELL, M. W.</creator><creator>LUE, C.</creator><creator>WALL BAKE, A. W. L.</creator><creator>MOLDOVEANU, Z.</creator><creator>MESTECKY, J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Blackwell</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199201</creationdate><title>Molecular heterogeneity of human IgA antibodies during an immune response</title><author>RUSSELL, M. W. ; LUE, C. ; WALL BAKE, A. W. L. ; MOLDOVEANU, Z. ; MESTECKY, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5341-846c93b39ac66f8da0d040d66521bd3013c66391b7686ee3a9e9e17ceaf98fcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Antibodies, immunoglobulins</topic><topic>Antibody Formation</topic><topic>antibody responses</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>IgA subclasses</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin A - classification</topic><topic>Immunoglobulin A - physiology</topic><topic>Immunology</topic><topic>Life Sciences & Biomedicine</topic><topic>Molecular immunology</topic><topic>polymeric/monomeric IgA</topic><topic>Science & Technology</topic><topic>Structure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RUSSELL, M. W.</creatorcontrib><creatorcontrib>LUE, C.</creatorcontrib><creatorcontrib>WALL BAKE, A. W. L.</creatorcontrib><creatorcontrib>MOLDOVEANU, Z.</creatorcontrib><creatorcontrib>MESTECKY, J.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RUSSELL, M. W.</au><au>LUE, C.</au><au>WALL BAKE, A. W. L.</au><au>MOLDOVEANU, Z.</au><au>MESTECKY, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular heterogeneity of human IgA antibodies during an immune response</atitle><jtitle>Clinical and experimental immunology</jtitle><stitle>CLIN EXP IMMUNOL</stitle><addtitle>Clin Exp Immunol</addtitle><date>1992-01</date><risdate>1992</risdate><volume>87</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>SUMMARY
Human IgA occurs in multiple molecular forms (polymeric and monomeric) and two subclasses which show differential distribution between the mucosal and circulatory compartments of the immune system. However, the molecular form and subclass of specific IgA antibodies are influenced, especially during an immune response, by the type of antigen and duration of the response as well as by the route of exposure. These considerations question previously held notions that polymeric IgA and an increased representation of the IgA2 subclass among circulating antibodies or antibody‐secreting cells signify their mucosal origin. Although the functional properties of different molecular forms and subclasses of IgA antibodies are incompletely understood, it appears that there is physiological benefit in the diversity of the IgA immune system.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1733625</pmid><doi>10.1111/j.1365-2249.1992.tb06404.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antibodies, immunoglobulins Antibody Formation antibody responses Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IgA subclasses Immunoglobulin A - analysis Immunoglobulin A - classification Immunoglobulin A - physiology Immunology Life Sciences & Biomedicine Molecular immunology polymeric/monomeric IgA Science & Technology Structure |
| title | Molecular heterogeneity of human IgA antibodies during an immune response |
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