Distribution of elements in teeth and inhibition of demineralization by titanium fluoride: Effects of concentration and pH in a titanium fluoride solution

The purpose of this study was to assess the effects of titanium fluoride (TiF4) concentration and pH on fluoride distribution and demineralization of root dentin surfaces. Concentrations of 0.1%, 1%, and 2% TiF4 (pH 1), 1% TiF4 solution adjusted to pH 4, 5, 6, and 1.35% sodium fluoride (NaF) solution were applied to root dentin surfaces. Each specimen was subjected to pH cycling (pH: 4.5–7.0) for 4 weeks. Lesion depth and calcium, fluorine, and titanium distribution were then evaluated. Our limited study indicates that lesion depth and fluorine and titanium distribution in dentin depend on the concentration of a TiF4 solution. We also found that a 1% TiF4 solution adjusted to a pH 4–6 can reduce demineralization as effectively as a similar concentration of NaF.