NLRP3 inflammasome induces CD4(+) T cell loss in chronically HIV-1-infected patients

Chronic HIV-1 infection is generally characterized by progressive CD4(+) T cell depletion due to direct and bystander death that is closely associated with persistent HIV-1 replication and an inflammatory environment in vivo. The mechanisms underlying the loss of CD4(+) T cells in patients with chro...

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Veröffentlicht in:	The Journal of clinical investigation 2021-03, Vol.131 (6), Article 138861
Hauptverfasser:	Zhang, Chao, Song, Jin-Wen, Huang, Hui-Huang, Fan, Xing, Huang, Lei, Deng, Jian-Ning, Tu, Bo, Wang, Kun, Li, Jing, Zhou, Ming-Ju, Yang, Cui-Xian, Zhao, Qi-Wen, Yang, Tao, Wang, Li-Feng, Zhang, Ji-Yuan, Xu, Ruo-Nan, Jiao, Yan-Mei, Shi, Ming, Shao, Feng, Sekaly, Rafick-Pierre, Wang, Fu-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences & Biomedicine Medicine, Research & Experimental Research & Experimental Medicine Science & Technology
Online-Zugang:	Volltext
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