Monitoring dynamic pre-crystallization aggregation processes in solution by VT-DOSY-NMR spectroscopy

Monitoring dynamic pre-crystallization aggregation processes in solution by VT-DOSY-NMR spectroscopy

Equimolar mixtures of pyridine (Py) with -halotetrafluoropyridine (BrTFP and ITFP) were investigated by VT-diffusion NMR experiments. The formation of a halogen-bond-stabilized ITFP Py complex was detected upon cooling a solution in methylcyclohexane- to 260 K; this allows monitoring a halogen-bond-...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-03, Vol.58 (21), p.3465-3468
Hauptverfasser: Mix, Andreas, Lamm, Jan-Hendrik, Schwabedissen, Jan, Gebel, Erich, Stammler, Hans-Georg, Mitzel, Norbert W
Format: Artikel
Sprache:eng
Schlagworte:
Agglomeration
Crystallization
Methylcyclohexane
Monitoring
NMR spectroscopy
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Zusammenfassung:Equimolar mixtures of pyridine (Py) with -halotetrafluoropyridine (BrTFP and ITFP) were investigated by VT-diffusion NMR experiments. The formation of a halogen-bond-stabilized ITFP Py complex was detected upon cooling a solution in methylcyclohexane- to 260 K; this allows monitoring a halogen-bond-driven aggregation process preceding crystallization in solution.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc05925d