PTP61F Mediates Cell Competition and Mitigates Tumorigenesis

Tissue homeostasis via the elimination of aberrant cells is fundamental for organism survival. Cell competition is a key homeostatic mechanism, contributing to the recognition and elimination of aberrant cells, preventing their malignant progression and the development of tumors. Here, using as a mo...

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Veröffentlicht in:	International journal of molecular sciences 2021-11, Vol.22 (23), p.12732
Hauptverfasser:	La Marca, John E, Willoughby, Lee F, Allan, Kirsten, Portela, Marta, Goh, Pei Kee, Tiganis, Tony, Richardson, Helena E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Cell Competition Cloning Competition Competitive advantage Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Endoplasmic reticulum Growth factors Homeostasis Insects JAK–STAT Janus Kinase 1 - genetics Janus Kinase 1 - metabolism Kinases Mammals MAP kinase Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Mutation Neoplasms - metabolism Neoplasms - pathology Neoplasms - prevention & control Phosphatase Phosphorylation Polarity Protein Tyrosine Phosphatases, Non-Receptor - genetics Protein Tyrosine Phosphatases, Non-Receptor - metabolism Protein-tyrosine-phosphatase Proteins PTP61F RAS Ras protein ras Proteins - genetics ras Proteins - metabolism Signal Transduction STAT Transcription Factors - genetics STAT Transcription Factors - metabolism Survival Tumor suppressor genes Tumorigenesis Tumors Twins Tyrosine
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