Carbamazepine-induced immune thrombocytopenia confirmed by modified MASPAT test

Carbamazepine-induced immune thrombocytopenia confirmed by modified MASPAT test

A 76-year-old man suffering post-herpetic neuralgia developed severe thrombocytopenia 15 days after the administration of carbamazepine. Carbamazepine-dependent platelet antibodies were proved to be present in the patient’s serum by a modified Monoclonal Antibody Solid-phase Platelet Antibody Test (...

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Veröffentlicht in:Transfusion and apheresis science 2021-12, Vol.60 (6), p.103228-103228, Article 103228
Hauptverfasser: Chen, Weiyuan, Lv, Xiaoying, Rong, Ruiming, Wu, Boting
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Carbamazepine
Carbamazepine - adverse effects
Drug-induced immune thrombocytopenia
Humans
Male
Purpura, Thrombocytopenic, Idiopathic - chemically induced
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Zusammenfassung:A 76-year-old man suffering post-herpetic neuralgia developed severe thrombocytopenia 15 days after the administration of carbamazepine. Carbamazepine-dependent platelet antibodies were proved to be present in the patient’s serum by a modified Monoclonal Antibody Solid-phase Platelet Antibody Test (MASPAT), and the diagnosis of carbamazepine-induced immune thrombocytopenia was confirmed. For the patient, carbamazepine should be advised to be avoided permanently. The present report advocated the application of a modified MASPAT test for the detection of carbamazepine-dependent platelet antibodies.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2021.103228