Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice

The nuclear receptors liver X receptor α (LXRα) and LXRβ are lipid sensors that regulate lipid metabolism and immunity. Natural killer T (NKT) cells, a T cell subset expressing surface markers of both natural killer cells and T lymphocytes and involved in antitumor immunity, are another abundant imm...

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Veröffentlicht in:	Scientific reports 2021-11, Vol.11 (1), p.22595-22595, Article 22595
Hauptverfasser:	Endo-Umeda, Kaori, Nakashima, Hiroyuki, Uno, Shigeyuki, Toyoshima, Shota, Umeda, Naoki, Komine-Aizawa, Shihoko, Seki, Shuhji, Makishima, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/580 631/337 Animals Antineoplastic Agents - pharmacology Antitumor activity Bone marrow Bone Marrow - metabolism Bone Marrow Transplantation Cell-mediated immunity Cytokines Cytokines - metabolism Galactosylceramide Galactosylceramides - metabolism Hepatocytes Humanities and Social Sciences Killer Cells, Natural - metabolism Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Lipid metabolism Liver Liver - drug effects Liver - metabolism Liver Neoplasms - pathology Liver X receptors Liver X Receptors - metabolism Lymphocytes Lymphocytes T Male Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary Multidisciplinary Sciences Natural killer cells Neoplasm Metastasis Nuclear receptors Rodents Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Spleen Spleen - cytology Spleen - metabolism Surface markers Thymocytes - cytology Thymus Thymus gland
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