Natural Progression of Ground-glass Nodules after Curative Resection for Non-small Cell Lung Cancer
Background: This retrospective study investigated the natural course of synchronous groundglass nodules (GGNs) that remained after curative resection for non-small-cell lung cancer (NSCLC). Methods: Prospectively collected retrospective data were reviewed concerning 2,276 patients who underwent cura...
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| Veröffentlicht in: | Journal of Korean medical science 2021, 36(43), , pp.1-9 |
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| creator | Lee, Kanghoon Kim, Hyeong Ryul Park, Seung-Il Kim, Dong Kwan Kim, Yong-Hee Choi, Sehoon Lee, Geun Dong |
| description | Background: This retrospective study investigated the natural course of synchronous groundglass nodules (GGNs) that remained after curative resection for non-small-cell lung cancer (NSCLC). Methods: Prospectively collected retrospective data were reviewed concerning 2,276 patients who underwent curative resection for NSCLC between 2008 and 2017. High-resolution computed tomography or thin-section computed tomography data of 82 patients were included in the study. Growth in size was considered the most valuable outcome, and patients were grouped according to GGN size change. Patient demographic data (e.g., age, sex, and smoking history), perioperative data (e.g., GGN characteristics, histopathology and pathological stage of the resected tumours), and other medical history were evaluated in a risk factor analysis concerning GGN size change. Results: The median duration of follow-up was 36.0 months (interquartile range, 23.0-59.3 months). GGN size decreased in 6 patients (7.3%), was stationary in 43 patients (52.4%), and increased in 33 patients (40.2%). In univariate analysis, male sex, the GGN size on initial CT, part-solid GGN and smoking history (>= 10 pack-years) were significant risk factors. Among them, multivariate analysis revealed that lager GGN size, part-solid GGN and smoking history were independent risk factors. Conclusion: During follow-up, 40.2% of GGNs increased in size, emphasising that patients with larger GGNs, part-solid GGN or with a smoking history should be observed. |
| doi_str_mv | 10.3346/jkms.2021.36.e266 |
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Methods: Prospectively collected retrospective data were reviewed concerning 2,276 patients who underwent curative resection for NSCLC between 2008 and 2017. High-resolution computed tomography or thin-section computed tomography data of 82 patients were included in the study. Growth in size was considered the most valuable outcome, and patients were grouped according to GGN size change. Patient demographic data (e.g., age, sex, and smoking history), perioperative data (e.g., GGN characteristics, histopathology and pathological stage of the resected tumours), and other medical history were evaluated in a risk factor analysis concerning GGN size change. Results: The median duration of follow-up was 36.0 months (interquartile range, 23.0-59.3 months). GGN size decreased in 6 patients (7.3%), was stationary in 43 patients (52.4%), and increased in 33 patients (40.2%). In univariate analysis, male sex, the GGN size on initial CT, part-solid GGN and smoking history (>= 10 pack-years) were significant risk factors. Among them, multivariate analysis revealed that lager GGN size, part-solid GGN and smoking history were independent risk factors. Conclusion: During follow-up, 40.2% of GGNs increased in size, emphasising that patients with larger GGNs, part-solid GGN or with a smoking history should be observed.</description><identifier>ISSN: 1011-8934</identifier><identifier>EISSN: 1598-6357</identifier><identifier>DOI: 10.3346/jkms.2021.36.e266</identifier><identifier>PMID: 34751007</identifier><language>eng</language><publisher>SEOUL: Korean Acad Medical Sciences</publisher><subject>Aged ; Area Under Curve ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - surgery ; Disease Progression ; Female ; General & Internal Medicine ; Humans ; Life Sciences & Biomedicine ; Logistic Models ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Medicine, General & Internal ; Middle Aged ; Multiple Pulmonary Nodules - pathology ; Original ; Retrospective Studies ; Risk Factors ; ROC Curve ; Science & Technology ; Smoking ; Tomography, X-Ray Computed ; 의학일반</subject><ispartof>Journal of Korean Medical Science, 2021, 36(43), , pp.1-9</ispartof><rights>2021 The Korean Academy of Medical Sciences.</rights><rights>2021 The Korean Academy of Medical Sciences. 2021 The Korean Academy of Medical Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000718125000007</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c433t-6b3674a5e6c00f1ec573ea3f1e5cfac8a21b2389120dc9b83dca69dd98e880cd3</citedby><cites>FETCH-LOGICAL-c433t-6b3674a5e6c00f1ec573ea3f1e5cfac8a21b2389120dc9b83dca69dd98e880cd3</cites><orcidid>0000-0001-5811-5407 ; 0000-0002-6691-7693 ; 0000-0002-8729-0498 ; 0000-0003-1890-7455 ; 0000-0002-9961-9289 ; 0000-0003-2177-4876 ; 0000-0003-1984-0352</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34751007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002774146$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Kanghoon</creatorcontrib><creatorcontrib>Kim, Hyeong Ryul</creatorcontrib><creatorcontrib>Park, Seung-Il</creatorcontrib><creatorcontrib>Kim, Dong Kwan</creatorcontrib><creatorcontrib>Kim, Yong-Hee</creatorcontrib><creatorcontrib>Choi, Sehoon</creatorcontrib><creatorcontrib>Lee, Geun Dong</creatorcontrib><title>Natural Progression of Ground-glass Nodules after Curative Resection for Non-small Cell Lung Cancer</title><title>Journal of Korean medical science</title><addtitle>J KOREAN MED SCI</addtitle><addtitle>J Korean Med Sci</addtitle><description>Background: This retrospective study investigated the natural course of synchronous groundglass nodules (GGNs) that remained after curative resection for non-small-cell lung cancer (NSCLC). Methods: Prospectively collected retrospective data were reviewed concerning 2,276 patients who underwent curative resection for NSCLC between 2008 and 2017. High-resolution computed tomography or thin-section computed tomography data of 82 patients were included in the study. Growth in size was considered the most valuable outcome, and patients were grouped according to GGN size change. Patient demographic data (e.g., age, sex, and smoking history), perioperative data (e.g., GGN characteristics, histopathology and pathological stage of the resected tumours), and other medical history were evaluated in a risk factor analysis concerning GGN size change. Results: The median duration of follow-up was 36.0 months (interquartile range, 23.0-59.3 months). GGN size decreased in 6 patients (7.3%), was stationary in 43 patients (52.4%), and increased in 33 patients (40.2%). In univariate analysis, male sex, the GGN size on initial CT, part-solid GGN and smoking history (>= 10 pack-years) were significant risk factors. Among them, multivariate analysis revealed that lager GGN size, part-solid GGN and smoking history were independent risk factors. Conclusion: During follow-up, 40.2% of GGNs increased in size, emphasising that patients with larger GGNs, part-solid GGN or with a smoking history should be observed.</description><subject>Aged</subject><subject>Area Under Curve</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Disease Progression</subject><subject>Female</subject><subject>General & Internal Medicine</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Logistic Models</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine, General & Internal</subject><subject>Middle Aged</subject><subject>Multiple Pulmonary Nodules - pathology</subject><subject>Original</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Science & Technology</subject><subject>Smoking</subject><subject>Tomography, X-Ray Computed</subject><subject>의학일반</subject><issn>1011-8934</issn><issn>1598-6357</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS1ERcvAA7BBWVKhTP0TO_YGqYqgVBq1qCpry3FuBncSu9hJEW-P0ykj2NUL-0r-zrHvPQi9I3jNWCXO7nZjWlNMyZqJNVAhXqATwpUsBeP1y1xjQkqpWHWMXqd0hzHlnLJX6JhVNScY1yfIXplpjmYovsWwjZCSC74IfXERw-y7cjuYlIqr0M0DpML0E8SiyfzkHqC4gQR2WgR9iBnyZRrNMBQN5G0z-23RGG8hvkFHvRkSvH06V-j7l8-3zddyc31x2ZxvSlsxNpWiZaKuDAdhMe4JWF4zMCxX3PbGSkNJS5lUhOLOqlayzhqhuk5JkBLbjq3Q6d7Xx17vrNPBuMdzG_Qu6vOb20utpOSYqsx-2rP3cztCZ8FPeQr6PrrRxN-Pyv9vvPuRfR605DWvBc8GH54MYvg5Q5r06JLNnRsPYU6acsW5UDi3tkJkj9oYUorQH54hWC9B6iVIvQSpmdBLkFnz_t__HRR_k8uA3AO_oA19sg7yqA8YzgiRhHK8rLpxk1mCanKoU5Z-fL6U_QHs3b0D</recordid><startdate>20211108</startdate><enddate>20211108</enddate><creator>Lee, Kanghoon</creator><creator>Kim, Hyeong Ryul</creator><creator>Park, Seung-Il</creator><creator>Kim, Dong Kwan</creator><creator>Kim, Yong-Hee</creator><creator>Choi, Sehoon</creator><creator>Lee, Geun Dong</creator><general>Korean Acad Medical Sciences</general><general>The Korean Academy of Medical Sciences</general><general>대한의학회</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0001-5811-5407</orcidid><orcidid>https://orcid.org/0000-0002-6691-7693</orcidid><orcidid>https://orcid.org/0000-0002-8729-0498</orcidid><orcidid>https://orcid.org/0000-0003-1890-7455</orcidid><orcidid>https://orcid.org/0000-0002-9961-9289</orcidid><orcidid>https://orcid.org/0000-0003-2177-4876</orcidid><orcidid>https://orcid.org/0000-0003-1984-0352</orcidid></search><sort><creationdate>20211108</creationdate><title>Natural Progression of Ground-glass Nodules after Curative Resection for Non-small Cell Lung Cancer</title><author>Lee, Kanghoon ; Kim, Hyeong Ryul ; Park, Seung-Il ; Kim, Dong Kwan ; Kim, Yong-Hee ; Choi, Sehoon ; Lee, Geun Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-6b3674a5e6c00f1ec573ea3f1e5cfac8a21b2389120dc9b83dca69dd98e880cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Area Under Curve</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Disease Progression</topic><topic>Female</topic><topic>General & Internal Medicine</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Logistic Models</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine, General & Internal</topic><topic>Middle Aged</topic><topic>Multiple Pulmonary Nodules - pathology</topic><topic>Original</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Science & Technology</topic><topic>Smoking</topic><topic>Tomography, X-Ray Computed</topic><topic>의학일반</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kanghoon</creatorcontrib><creatorcontrib>Kim, Hyeong Ryul</creatorcontrib><creatorcontrib>Park, Seung-Il</creatorcontrib><creatorcontrib>Kim, Dong Kwan</creatorcontrib><creatorcontrib>Kim, Yong-Hee</creatorcontrib><creatorcontrib>Choi, Sehoon</creatorcontrib><creatorcontrib>Lee, Geun Dong</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Journal of Korean medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kanghoon</au><au>Kim, Hyeong Ryul</au><au>Park, Seung-Il</au><au>Kim, Dong Kwan</au><au>Kim, Yong-Hee</au><au>Choi, Sehoon</au><au>Lee, Geun Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural Progression of Ground-glass Nodules after Curative Resection for Non-small Cell Lung Cancer</atitle><jtitle>Journal of Korean medical science</jtitle><stitle>J KOREAN MED SCI</stitle><addtitle>J Korean Med Sci</addtitle><date>2021-11-08</date><risdate>2021</risdate><volume>36</volume><issue>43</issue><spage>e266</spage><epage>e266</epage><pages>e266-e266</pages><artnum>266</artnum><issn>1011-8934</issn><eissn>1598-6357</eissn><abstract>Background: This retrospective study investigated the natural course of synchronous groundglass nodules (GGNs) that remained after curative resection for non-small-cell lung cancer (NSCLC). Methods: Prospectively collected retrospective data were reviewed concerning 2,276 patients who underwent curative resection for NSCLC between 2008 and 2017. High-resolution computed tomography or thin-section computed tomography data of 82 patients were included in the study. Growth in size was considered the most valuable outcome, and patients were grouped according to GGN size change. Patient demographic data (e.g., age, sex, and smoking history), perioperative data (e.g., GGN characteristics, histopathology and pathological stage of the resected tumours), and other medical history were evaluated in a risk factor analysis concerning GGN size change. Results: The median duration of follow-up was 36.0 months (interquartile range, 23.0-59.3 months). GGN size decreased in 6 patients (7.3%), was stationary in 43 patients (52.4%), and increased in 33 patients (40.2%). In univariate analysis, male sex, the GGN size on initial CT, part-solid GGN and smoking history (>= 10 pack-years) were significant risk factors. Among them, multivariate analysis revealed that lager GGN size, part-solid GGN and smoking history were independent risk factors. Conclusion: During follow-up, 40.2% of GGNs increased in size, emphasising that patients with larger GGNs, part-solid GGN or with a smoking history should be observed.</abstract><cop>SEOUL</cop><pub>Korean Acad Medical Sciences</pub><pmid>34751007</pmid><doi>10.3346/jkms.2021.36.e266</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5811-5407</orcidid><orcidid>https://orcid.org/0000-0002-6691-7693</orcidid><orcidid>https://orcid.org/0000-0002-8729-0498</orcidid><orcidid>https://orcid.org/0000-0003-1890-7455</orcidid><orcidid>https://orcid.org/0000-0002-9961-9289</orcidid><orcidid>https://orcid.org/0000-0003-2177-4876</orcidid><orcidid>https://orcid.org/0000-0003-1984-0352</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Area Under Curve Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Disease Progression Female General & Internal Medicine Humans Life Sciences & Biomedicine Logistic Models Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Lung Neoplasms - surgery Male Medicine, General & Internal Middle Aged Multiple Pulmonary Nodules - pathology Original Retrospective Studies Risk Factors ROC Curve Science & Technology Smoking Tomography, X-Ray Computed 의학일반 |
| title | Natural Progression of Ground-glass Nodules after Curative Resection for Non-small Cell Lung Cancer |
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