Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection

A diverse group of antimicrobial proteins (AMPs) helps protect the mammalian intestine from varied microbial challenges. We show that small proline-rich protein 2A (SPRR2A) is an intestinal antibacterial protein that is phylogenetically unrelated to previously discovered mammalian AMPs. In this stud...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-11, Vol.374 (6568), p.eabe6723-eabe6723, Article 6723
Hauptverfasser:	Hu, Zehan, Zhang, Chenlu, Sifuentes-Dominguez, Luis, Zarek, Christina M., Propheter, Daniel C., Kuang, Zheng, Wang, Yuhao, Pendse, Mihir, Ruhn, Kelly A., Hassell, Brian, Behrendt, Cassie L., Zhang, Bo, Raj, Prithvi, Harris-Tryon, Tamia A., Reese, Tiffany A., Hooper, Lora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiinfectives and antibacterials Bacteria Bacterial diseases Bacterial infections Bacterial Load Bactericidal activity Biological activity Biopsy Cell Membrane - metabolism Cell Membrane Permeability Cell membranes Cell walls Colonization Composition Control Groups Cornified Envelope Proline-Rich Proteins - genetics Cornified Envelope Proline-Rich Proteins - metabolism Critical components Cytokines Cytokines - metabolism Damage Deactivation Digestive system Disease Susceptibility Disruption Epithelium Gastrointestinal Microbiome Gastrointestinal tract Goblet cells Goblet Cells - metabolism Gram-negative bacteria Gram-positive bacteria Gram-Positive Bacteria - physiology Humans Immune system Immunity Immunity, Innate Immunology Infections Inflammatory bowel diseases Interleukin 13 Interleukin 4 Intestinal microflora Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestine Intestines - microbiology Land Settlement Lipids Listeria Listeria monocytogenes Listeria monocytogenes - physiology Listeriosis - microbiology Lysozyme Mammals Membrane structures Membranes Mice Microbial activity Microbial Viability Microbiota Microorganisms Mucosa Multidisciplinary Sciences Nematospiroides dubius Paneth cells Paneth Cells - metabolism Parasites Phylogeny Pore Forming Cytotoxic Proteins - genetics Pore Forming Cytotoxic Proteins - metabolism Proline Proteins Science & Technology Science & Technology - Other Topics Small intestine Strongylida Infections - immunology Strongylida Infections - metabolism Strongylida Infections - microbiology Worms
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