A Clinical Trial of Prophylactic Prostatectomy for BRCA2 Mutation Carriers: Is Now the Time?

A Clinical Trial of Prophylactic Prostatectomy for BRCA2 Mutation Carriers: Is Now the Time?

The greater availability and use of genetic testing have improved our ability to determine that men with BRCA2 mutations are at significantly higher risk of developing and dying of prostate cancer. We should continue research efforts in secondary prevention for this population, but must also explore...

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Veröffentlicht in:European urology focus 2021-05, Vol.7 (3), p.506-507
Hauptverfasser: Clark, Roderick, McAlpine, Kristen, Fleshner, Neil
Format: Artikel
Sprache:eng
Schlagworte:
BRCA2 Protein - genetics
Clinical Trials as Topic
Genes, BRCA2
Genetic Testing
Humans
Male
Mutation
Prostatectomy
Prostatic Neoplasms - genetics
Prostatic Neoplasms - prevention & control
Prostatic Neoplasms - surgery
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Zusammenfassung:The greater availability and use of genetic testing have improved our ability to determine that men with BRCA2 mutations are at significantly higher risk of developing and dying of prostate cancer. We should continue research efforts in secondary prevention for this population, but must also explore primary preventative strategies such as prophylactic prostatectomy. Efforts are under way at our institution for a clinical trial in this area.
ISSN:2405-4569
2405-4569
DOI:10.1016/j.euf.2021.04.018