Antinociceptive and Anti-Inflammatory Effects of Recombinant Crotamine in Mouse Models of Pain

Crotamine, a toxin found in the venom of the South American rattlesnake Crotalus durissus terrificus, has been reported to have antinociceptive effects. We purified recombinant crotamine expressed in Escherichia coli and investigated its antinociceptive and anti-inflammatory effects using the hot-pl...

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Veröffentlicht in:	Toxins 2021-10, Vol.13 (10), p.707, Article 707
Hauptverfasser:	Park, Jong Yeon, Do, Bich Hang, Lee, Ju-Seung, Yang, Hyun Cheol, Nguyen, Anh Ngoc, Krupa, Martin, Kim, Chong Jai, Jang, Yeon Jin, Choe, Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics - pharmacology Animal models Animals Anti-Inflammatory Agents - pharmacology Crotalid Venoms - pharmacology crotamine Disease Models, Animal E coli Enzyme-linked immunosorbent assay Food Science & Technology Formaldehyde Glycerol Inflammation Life Sciences & Biomedicine Male Mice Mice, Inbred ICR Naloxone Narcotics nociception Opioid receptors Pain Pain - drug therapy Pain perception Pretreatment Proteins Science & Technology Toxicology Toxins Tumor necrosis factor-TNF Tumor necrosis factor-α Venom
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