Neuroprotective Effect of Lutein in Scopolamine-Induced Alzheimer’s Disease in Mice and Zebrafish

Lutein, a dietary antioxidant, can be a potent treatment for Alzheimer’s disease. In this study, the neuroprotective effect of lutein against scopolamine-induced learning and memory impairment was studied in zebrafish and mice. Lutein significantly ameliorated the effects of scopolamine on escape spatial learning and memory. Biochemical and histopathological investigation revealed that oral treatment of lutein shows neuroprotective effects in the pathogenesis of Alzheimer’s disease by regulating lipid peroxidation and reducing oxidative stress in the hippocampus of scopolamine-treated mice and zebrafish. These study results indicate that lutein possesses anti-amnesic property via acetylcholine esterase inhibition and regulation of lipid peroxidation in neuronal cell. Hence, lutein could be a potential compound to treat Alzheimer’s disease. Graphical Abstract