The emerging roles of neutrophil extracellular traps in wound healing
Delayed wound healing causes problems for many patients both physically and psychologically, contributing to pain, economic burden, loss of function, and even amputation. Although many factors affect the wound healing process, abnormally prolonged or augmented inflammation in the wound site is a com...
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| Veröffentlicht in: | Cell death & disease 2021-10, Vol.12 (11), p.984-984, Article 984 |
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| creator | Zhu, Shuainan Yu, Ying Ren, Yun Xu, Liying Wang, Huilin Ling, Xiaomin Jin, Lin Hu, Yan Zhang, Hao Miao, Changhong Guo, Kefang |
| description | Delayed wound healing causes problems for many patients both physically and psychologically, contributing to pain, economic burden, loss of function, and even amputation. Although many factors affect the wound healing process, abnormally prolonged or augmented inflammation in the wound site is a common cause of poor wound healing. Excessive neutrophil extracellular trap (NET) formation during this phase may amplify inflammation and hinder wound healing. However, the roles of NETs in wound healing are still unclear. Herein, we briefly introduce NET formation and discuss the possible NET-related mechanisms in wound healing. We conclude with a discussion of current studies, focusing on the roles of NETs in diabetic and normoglycemic wounds and the effectiveness of NET-targeting treatments in wound healing. |
| doi_str_mv | 10.1038/s41419-021-04294-3 |
| format | Article |
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Although many factors affect the wound healing process, abnormally prolonged or augmented inflammation in the wound site is a common cause of poor wound healing. Excessive neutrophil extracellular trap (NET) formation during this phase may amplify inflammation and hinder wound healing. However, the roles of NETs in wound healing are still unclear. Herein, we briefly introduce NET formation and discuss the possible NET-related mechanisms in wound healing. We conclude with a discussion of current studies, focusing on the roles of NETs in diabetic and normoglycemic wounds and the effectiveness of NET-targeting treatments in wound healing.</description><identifier>ISSN: 2041-4889</identifier><identifier>EISSN: 2041-4889</identifier><identifier>DOI: 10.1038/s41419-021-04294-3</identifier><identifier>PMID: 34686654</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/80/304 ; 692/308/1426 ; Amputation ; Animals ; Antibodies ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cell Culture ; Diabetes mellitus ; Extracellular Traps - metabolism ; Humans ; Immunology ; Inflammation ; Leukocytes (neutrophilic) ; Life Sciences ; Life Sciences & Biomedicine ; Mice ; Neutrophils ; Neutrophils - metabolism ; Review ; Review Article ; Science & Technology ; Wound healing ; Wound Healing - genetics</subject><ispartof>Cell death & disease, 2021-10, Vol.12 (11), p.984-984, Article 984</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>70</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000710150200001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c606t-ecf48dbb065fa6c1b6ff63af13a29ca777f9a3ce7d915998072956047941d8ce3</citedby><cites>FETCH-LOGICAL-c606t-ecf48dbb065fa6c1b6ff63af13a29ca777f9a3ce7d915998072956047941d8ce3</cites><orcidid>0000-0001-5973-7080 ; 0000-0001-6622-2587 ; 0000-0002-3406-8877</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536667/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536667/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2118,27933,27934,39267,41129,42198,51585,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34686654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Shuainan</creatorcontrib><creatorcontrib>Yu, Ying</creatorcontrib><creatorcontrib>Ren, Yun</creatorcontrib><creatorcontrib>Xu, Liying</creatorcontrib><creatorcontrib>Wang, Huilin</creatorcontrib><creatorcontrib>Ling, Xiaomin</creatorcontrib><creatorcontrib>Jin, Lin</creatorcontrib><creatorcontrib>Hu, Yan</creatorcontrib><creatorcontrib>Zhang, Hao</creatorcontrib><creatorcontrib>Miao, Changhong</creatorcontrib><creatorcontrib>Guo, Kefang</creatorcontrib><title>The emerging roles of neutrophil extracellular traps in wound healing</title><title>Cell death & disease</title><addtitle>Cell Death Dis</addtitle><addtitle>CELL DEATH DIS</addtitle><addtitle>Cell Death Dis</addtitle><description>Delayed wound healing causes problems for many patients both physically and psychologically, contributing to pain, economic burden, loss of function, and even amputation. Although many factors affect the wound healing process, abnormally prolonged or augmented inflammation in the wound site is a common cause of poor wound healing. Excessive neutrophil extracellular trap (NET) formation during this phase may amplify inflammation and hinder wound healing. However, the roles of NETs in wound healing are still unclear. Herein, we briefly introduce NET formation and discuss the possible NET-related mechanisms in wound healing. We conclude with a discussion of current studies, focusing on the roles of NETs in diabetic and normoglycemic wounds and the effectiveness of NET-targeting treatments in wound healing.</description><subject>631/80/304</subject><subject>692/308/1426</subject><subject>Amputation</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Diabetes mellitus</subject><subject>Extracellular Traps - metabolism</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Leukocytes (neutrophilic)</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Mice</subject><subject>Neutrophils</subject><subject>Neutrophils - metabolism</subject><subject>Review</subject><subject>Review Article</subject><subject>Science & Technology</subject><subject>Wound healing</subject><subject>Wound Healing - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cell death & disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Shuainan</au><au>Yu, Ying</au><au>Ren, Yun</au><au>Xu, Liying</au><au>Wang, Huilin</au><au>Ling, Xiaomin</au><au>Jin, Lin</au><au>Hu, Yan</au><au>Zhang, Hao</au><au>Miao, Changhong</au><au>Guo, Kefang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The emerging roles of neutrophil extracellular traps in wound healing</atitle><jtitle>Cell death & disease</jtitle><stitle>Cell Death Dis</stitle><stitle>CELL DEATH DIS</stitle><addtitle>Cell Death Dis</addtitle><date>2021-10-22</date><risdate>2021</risdate><volume>12</volume><issue>11</issue><spage>984</spage><epage>984</epage><pages>984-984</pages><artnum>984</artnum><issn>2041-4889</issn><eissn>2041-4889</eissn><abstract>Delayed wound healing causes problems for many patients both physically and psychologically, contributing to pain, economic burden, loss of function, and even amputation. 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| subjects | 631/80/304 692/308/1426 Amputation Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Diabetes mellitus Extracellular Traps - metabolism Humans Immunology Inflammation Leukocytes (neutrophilic) Life Sciences Life Sciences & Biomedicine Mice Neutrophils Neutrophils - metabolism Review Review Article Science & Technology Wound healing Wound Healing - genetics |
| title | The emerging roles of neutrophil extracellular traps in wound healing |
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