Ethnic discrimination and depressed mood: The role of autonomic regulation
Perceived ethnic discrimination (PED) is thought to underlie increased prevalence of depressed mood in ethnic minorities. Depression is associated with increased sympathetic and decreased parasympathetic activity. We investigated a biopsychosocial model linking PED, disrupted sympathovagal balance a...
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| Veröffentlicht in: | Journal of psychiatric research 2021-12, Vol.144, p.110-117 |
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| creator | Hagen, Julia M. Sutterland, Arjen L. Collard, Didier de Jonge, Carien D.E. van Zuiden, Mirjam Zantvoord, Jasper B. Tan, Hanno L. van Valkengoed, Irene G.M. van den Born, Bert Jan H. Zwinderman, Aeilko H. de Haan, Lieuwe Lok, Anja |
| description | Perceived ethnic discrimination (PED) is thought to underlie increased prevalence of depressed mood in ethnic minorities. Depression is associated with increased sympathetic and decreased parasympathetic activity. We investigated a biopsychosocial model linking PED, disrupted sympathovagal balance and depressed mood. Baseline data of HELIUS, a cohort study on health among a multi-ethnic population, was used. Heart rate variability (HRV), baroreflex sensitivity (BRS), PED (evaluated with the Everyday Discrimination Scale) and presence of depressed mood (evaluated with the Patient Health Questionnaire-9) were assessed. Associations of PED, HRV/BRS and depressed mood were analyzed with linear and logistic regression analyses. Mediation of the association of PED and depressed mood by HRV/BRS was assessed in a potential outcomes model and four steps mediation analysis. Of 9492 included participants, 14.7% fulfilled criteria for depressed mood. Higher PED was associated with depressed mood (P |
| doi_str_mv | 10.1016/j.jpsychires.2021.09.048 |
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•In a large multi-ethnic cohort, lower HRV and BRS indicating increased sympathetic tone were associated with depressed mood.•Lower HRV and BRS were at most weakly associated with perceived ethnic discrimination.•No evidence that autonomic dysregulation in response to ethnic discrimination relevantly increases chance of depressed mood.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2021.09.048</identifier><identifier>PMID: 34619489</identifier><language>eng</language><publisher>OXFORD: Elsevier Ltd</publisher><subject>Autonomic Nervous System ; Baroreflex ; Cohort Studies ; Depression ; Depressive disorders ; Ethnic discrimination ; Ethnicity ; Heart Rate ; Heart rate variability ; Humans ; Life Sciences & Biomedicine ; Psychiatry ; Racial discrimination ; Science & Technology</subject><ispartof>Journal of psychiatric research, 2021-12, Vol.144, p.110-117</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>0</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000707671500015</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c369t-eeda63bf2c356a6492cc4bf68cd084206beeb6032f9cfab49f123fe5d911ea563</cites><orcidid>0000-0002-5085-1108 ; 0000-0002-6475-902X ; 0000-0001-8572-8751</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychires.2021.09.048$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,39262,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34619489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagen, Julia M.</creatorcontrib><creatorcontrib>Sutterland, Arjen L.</creatorcontrib><creatorcontrib>Collard, Didier</creatorcontrib><creatorcontrib>de Jonge, Carien D.E.</creatorcontrib><creatorcontrib>van Zuiden, Mirjam</creatorcontrib><creatorcontrib>Zantvoord, Jasper B.</creatorcontrib><creatorcontrib>Tan, Hanno L.</creatorcontrib><creatorcontrib>van Valkengoed, Irene G.M.</creatorcontrib><creatorcontrib>van den Born, Bert Jan H.</creatorcontrib><creatorcontrib>Zwinderman, Aeilko H.</creatorcontrib><creatorcontrib>de Haan, Lieuwe</creatorcontrib><creatorcontrib>Lok, Anja</creatorcontrib><title>Ethnic discrimination and depressed mood: The role of autonomic regulation</title><title>Journal of psychiatric research</title><addtitle>J PSYCHIATR RES</addtitle><addtitle>J Psychiatr Res</addtitle><description>Perceived ethnic discrimination (PED) is thought to underlie increased prevalence of depressed mood in ethnic minorities. Depression is associated with increased sympathetic and decreased parasympathetic activity. We investigated a biopsychosocial model linking PED, disrupted sympathovagal balance and depressed mood. Baseline data of HELIUS, a cohort study on health among a multi-ethnic population, was used. Heart rate variability (HRV), baroreflex sensitivity (BRS), PED (evaluated with the Everyday Discrimination Scale) and presence of depressed mood (evaluated with the Patient Health Questionnaire-9) were assessed. Associations of PED, HRV/BRS and depressed mood were analyzed with linear and logistic regression analyses. Mediation of the association of PED and depressed mood by HRV/BRS was assessed in a potential outcomes model and four steps mediation analysis. Of 9492 included participants, 14.7% fulfilled criteria for depressed mood. Higher PED was associated with depressed mood (P < .001). Lower autonomic regulation indexes were associated with depressed mood (deltaR2 = 0.4–1.1%, P < .001) and at most weakly with PED (deltaR2 = 0.2–0.3%, P < .001). A very modest mediating effect by HRV/BRS in the association between PED and depressed mood was attenuated after adjustment for socioeconomic status. To conclude, we found no support for the hypothesis that autonomic regulation relevantly mediates the association between PED and depression.
•In a large multi-ethnic cohort, lower HRV and BRS indicating increased sympathetic tone were associated with depressed mood.•Lower HRV and BRS were at most weakly associated with perceived ethnic discrimination.•No evidence that autonomic dysregulation in response to ethnic discrimination relevantly increases chance of depressed mood.</description><subject>Autonomic Nervous System</subject><subject>Baroreflex</subject><subject>Cohort Studies</subject><subject>Depression</subject><subject>Depressive disorders</subject><subject>Ethnic discrimination</subject><subject>Ethnicity</subject><subject>Heart Rate</subject><subject>Heart rate variability</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Psychiatry</subject><subject>Racial discrimination</subject><subject>Science & Technology</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>GIZIO</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyAfkVDC2E6cmBusypcqcSlny7HHrFdJvNhJUf893u7SHuHkObzP-J2HEMqgZsDku329P-Q7uwsJc82BsxpUDU3_hGxY36mKiU49JRsAziuhWnlBXuS8B4COs-Y5uRCNZKrp1YZ8u1p2c7DUhWxTmMJslhBnamZHHR7K-oyOTjG69_RmhzTFEWn01KxLnONUwIQ_1_EeekmeeTNmfHV-L8mPT1c32y_V9ffPX7cfrisrpFoqRGekGDy3opVGNopb2wxe9tZB33CQA-IgQXCvrDdDozzjwmPrFGNoWikuyZvT3kOKv1bMi55KeRxHM2Ncs-ZtD1JJxY7R_hS1Keac0OtDOdKkO81AH03qvX40qY8mNShdTBb09fmXdZjQPYB_1ZXA21PgNw7RZxtwtvgQO7qGTnasLRNrH5v8T3oblnuj27jOS0E_nlAsUm8DJn3GXSltF-1i-Pc5fwDFRaw2</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Hagen, Julia M.</creator><creator>Sutterland, Arjen L.</creator><creator>Collard, Didier</creator><creator>de Jonge, Carien D.E.</creator><creator>van Zuiden, Mirjam</creator><creator>Zantvoord, Jasper B.</creator><creator>Tan, Hanno L.</creator><creator>van Valkengoed, Irene G.M.</creator><creator>van den Born, Bert Jan H.</creator><creator>Zwinderman, Aeilko H.</creator><creator>de Haan, Lieuwe</creator><creator>Lok, Anja</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>GIZIO</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5085-1108</orcidid><orcidid>https://orcid.org/0000-0002-6475-902X</orcidid><orcidid>https://orcid.org/0000-0001-8572-8751</orcidid></search><sort><creationdate>202112</creationdate><title>Ethnic discrimination and depressed mood: The role of autonomic regulation</title><author>Hagen, Julia M. ; Sutterland, Arjen L. ; Collard, Didier ; de Jonge, Carien D.E. ; van Zuiden, Mirjam ; Zantvoord, Jasper B. ; Tan, Hanno L. ; van Valkengoed, Irene G.M. ; van den Born, Bert Jan H. ; Zwinderman, Aeilko H. ; de Haan, Lieuwe ; Lok, Anja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-eeda63bf2c356a6492cc4bf68cd084206beeb6032f9cfab49f123fe5d911ea563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Autonomic Nervous System</topic><topic>Baroreflex</topic><topic>Cohort Studies</topic><topic>Depression</topic><topic>Depressive disorders</topic><topic>Ethnic discrimination</topic><topic>Ethnicity</topic><topic>Heart Rate</topic><topic>Heart rate variability</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Psychiatry</topic><topic>Racial discrimination</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hagen, Julia M.</creatorcontrib><creatorcontrib>Sutterland, Arjen L.</creatorcontrib><creatorcontrib>Collard, Didier</creatorcontrib><creatorcontrib>de Jonge, Carien D.E.</creatorcontrib><creatorcontrib>van Zuiden, Mirjam</creatorcontrib><creatorcontrib>Zantvoord, Jasper B.</creatorcontrib><creatorcontrib>Tan, Hanno L.</creatorcontrib><creatorcontrib>van Valkengoed, Irene G.M.</creatorcontrib><creatorcontrib>van den Born, Bert Jan H.</creatorcontrib><creatorcontrib>Zwinderman, Aeilko H.</creatorcontrib><creatorcontrib>de Haan, Lieuwe</creatorcontrib><creatorcontrib>Lok, Anja</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Web of Knowledge</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Web of Science - Social Sciences Citation Index – 2021</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagen, Julia M.</au><au>Sutterland, Arjen L.</au><au>Collard, Didier</au><au>de Jonge, Carien D.E.</au><au>van Zuiden, Mirjam</au><au>Zantvoord, Jasper B.</au><au>Tan, Hanno L.</au><au>van Valkengoed, Irene G.M.</au><au>van den Born, Bert Jan H.</au><au>Zwinderman, Aeilko H.</au><au>de Haan, Lieuwe</au><au>Lok, Anja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethnic discrimination and depressed mood: The role of autonomic regulation</atitle><jtitle>Journal of psychiatric research</jtitle><stitle>J PSYCHIATR RES</stitle><addtitle>J Psychiatr Res</addtitle><date>2021-12</date><risdate>2021</risdate><volume>144</volume><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Perceived ethnic discrimination (PED) is thought to underlie increased prevalence of depressed mood in ethnic minorities. Depression is associated with increased sympathetic and decreased parasympathetic activity. We investigated a biopsychosocial model linking PED, disrupted sympathovagal balance and depressed mood. Baseline data of HELIUS, a cohort study on health among a multi-ethnic population, was used. Heart rate variability (HRV), baroreflex sensitivity (BRS), PED (evaluated with the Everyday Discrimination Scale) and presence of depressed mood (evaluated with the Patient Health Questionnaire-9) were assessed. Associations of PED, HRV/BRS and depressed mood were analyzed with linear and logistic regression analyses. Mediation of the association of PED and depressed mood by HRV/BRS was assessed in a potential outcomes model and four steps mediation analysis. Of 9492 included participants, 14.7% fulfilled criteria for depressed mood. Higher PED was associated with depressed mood (P < .001). Lower autonomic regulation indexes were associated with depressed mood (deltaR2 = 0.4–1.1%, P < .001) and at most weakly with PED (deltaR2 = 0.2–0.3%, P < .001). A very modest mediating effect by HRV/BRS in the association between PED and depressed mood was attenuated after adjustment for socioeconomic status. To conclude, we found no support for the hypothesis that autonomic regulation relevantly mediates the association between PED and depression.
•In a large multi-ethnic cohort, lower HRV and BRS indicating increased sympathetic tone were associated with depressed mood.•Lower HRV and BRS were at most weakly associated with perceived ethnic discrimination.•No evidence that autonomic dysregulation in response to ethnic discrimination relevantly increases chance of depressed mood.</abstract><cop>OXFORD</cop><pub>Elsevier Ltd</pub><pmid>34619489</pmid><doi>10.1016/j.jpsychires.2021.09.048</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5085-1108</orcidid><orcidid>https://orcid.org/0000-0002-6475-902X</orcidid><orcidid>https://orcid.org/0000-0001-8572-8751</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Autonomic Nervous System Baroreflex Cohort Studies Depression Depressive disorders Ethnic discrimination Ethnicity Heart Rate Heart rate variability Humans Life Sciences & Biomedicine Psychiatry Racial discrimination Science & Technology |
| title | Ethnic discrimination and depressed mood: The role of autonomic regulation |
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