Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes

Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecu...

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Veröffentlicht in:	Scientific reports 2021-10, Vol.11 (1), p.20289-20289, Article 20289
Hauptverfasser:	Molina, Israel, Marcolino, Milena Soriano, Pires, Magda Carvalho, Ramos, Lucas Emanuel Ferreira, Silva, Rafael Tavares, Guimarães-Júnior, Milton Henriques, de Oliveira, Isaias José Ramos, de Carvalho, Rafael Lima Rodrigues, Nunes, Aline Gabrielle Sousa, de Barros, Ana Lara Rodrigues Monteiro, Scotton, Ana Luiza Bahia Alves, Madureira, Angélica Aparecida Coelho, Farace, Bárbara Lopes, de Carvalho, Cíntia Alcantara, Rodrigues, Fernanda d’Athayde, Anschau, Fernando, Botoni, Fernando Antonio, Nascimento, Guilherme Fagundes, Duani, Helena, Guimarães, Henrique Cerqueira, de Alvarenga, Joice Coutinho, Moreira, Leila Beltrami, Zandoná, Liege Barella, de Almeida, Luana Fonseca, Oliveira, Luana Martins, Kopittke, Luciane, de Castro, Luís César, Santos, Luisa Elem Almeida, de Souza Cabral, Máderson Alvares, Ferreira, Maria Angélica Pires, da Cunha Severino Sampaio, Natália, de Oliveira, Neimy Ramos, Assaf, Pedro Ledic, Lopes, Sofia Jarjour Tavares Starling, Fereguetti, Tatiani Oliveira, dos Santos, Veridiana Baldon, de Carvalho, Victor Eliel Bastos, Ramires, Yuri Carlotto, Ribeiro, Antonio Luiz Pinho, Moscoso, Freddy Antonio Brito, Moura, Rogério, Polanczyk, Carísi Anne, do Carmo Pereira Nunes, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326 631/326/596 631/326/596/4130 692/308 692/308/174 692/4019 692/699 692/700 C-reactive protein Cardiac arrhythmia Chagas disease Congestive heart failure Coronaviruses COVID-19 Diabetes mellitus Fibrillation Heart failure Humanities and Social Sciences Hypertension multidisciplinary Patients Public health Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Vector-borne diseases
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Zusammenfassung:	Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64–80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-96825-3