Genome-wide detection of cytosine methylations in plant from Nanopore data using deep learning

In plants, cytosine DNA methylations (5mCs) can happen in three sequence contexts as CpG, CHG, and CHH (where H = A, C, or T), which play different roles in the regulation of biological processes. Although long Nanopore reads are advantageous in the detection of 5mCs comparing to short-read bisulfit...

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Veröffentlicht in:	Nature communications 2021-10, Vol.12 (1), p.5976-11, Article 5976
Hauptverfasser:	Ni, Peng, Huang, Neng, Nie, Fan, Zhang, Jun, Zhang, Zhi, Wu, Bo, Bai, Lu, Liu, Wende, Xiao, Chuan-Le, Luo, Feng, Wang, Jianxin
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/114/2397 631/208/176/1988 631/208/2491 Arabidopsis - genetics Arabidopsis - metabolism Biological activity Bisulfite CpG Islands Cytosine Cytosine - metabolism Deep Learning Deoxyribonucleic acid DNA DNA Methylation DNA, Plant - genetics DNA, Plant - metabolism Epigenesis, Genetic Epigenetics Genome, Plant Genomes High-Throughput Nucleotide Sequencing - methods Humanities and Social Sciences multidisciplinary Multidisciplinary Sciences Nanopores Nucleotide sequence Oryza - genetics Oryza - metabolism Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Sequence Analysis, DNA Sulfites - chemistry
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