Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically found at low levels in the respiratory tract 1 – 3 , suggesting that there may be additional mechanisms facilitating infection. Here we s...

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Veröffentlicht in:	Nature (London) 2021-10, Vol.598 (7880), p.342-347
Hauptverfasser:	Lempp, Florian A., Soriaga, Leah B., Montiel-Ruiz, Martin, Benigni, Fabio, Noack, Julia, Park, Young-Jun, Bianchi, Siro, Walls, Alexandra C., Bowen, John E., Zhou, Jiayi, Kaiser, Hannah, Joshi, Anshu, Agostini, Maria, Meury, Marcel, Dellota, Exequiel, Jaconi, Stefano, Cameroni, Elisabetta, Martinez-Picado, Javier, Vergara-Alert, Júlia, Izquierdo-Useros, Nuria, Virgin, Herbert W., Lanzavecchia, Antonio, Veesler, David, Purcell, Lisa A., Telenti, Amalio, Corti, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 13/1 13/109 13/31 13/89 14/19 14/63 631/250/2152/2153/1291 631/250/255/2514 631/326/596/4130 ACE2 Angiotensin Angiotensin converting enzyme Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Animals Antibodies Antibodies, Neutralizing - immunology Antigens Binding Cell adhesion Cell Adhesion Molecules - metabolism Cell Fusion Cell Line COVID-19 Cricetinae Datasets DC-SIGN protein Dendritic cells Domains Female Health aspects Humanities and Social Sciences Humans Infections Lectins Lectins - immunology Lectins - metabolism Lectins, C-Type - metabolism Membrane Fusion Monoclonal antibodies multidisciplinary Neutralization Neutralizing Peptidyl-dipeptidase A Physiological aspects Receptor mechanisms Receptors Receptors, Cell Surface - metabolism Respiratory tract SARS-CoV-2 - immunology SARS-CoV-2 - metabolism SARS-CoV-2 - pathogenicity Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Sialic Acid Binding Ig-like Lectin 1 - metabolism Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Viral infections
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