Association of Helicobacter pylori vacA polymorphisms with the risk of gastric precancerous lesions in a Moroccan population
Introduction: Helicobacter pylori infection is the major risk factor of atrophic gastritis and intestinal metaplasia. The vacA gene is one of the most virulence factors of H. pylori and genetic diversity in its s, m, i, and d regions is associated with gastric lesions severity. This study aimed to i...
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| creator | Jouimyi, Mohamed Reda Bounder, Ghizlane Essaidi, Imane Boura, Hasna Badre, Wafaa Benomar, Hakima Zerouali, Khalid Lebrazi, Halima Kettani, Anass Maachi, Fatima |
| description | Introduction: Helicobacter pylori infection is the major risk factor of atrophic gastritis and intestinal metaplasia. The vacA gene is one of the most virulence factors of H. pylori and genetic diversity in its s, m, i, and d regions is associated with gastric lesions severity. This study aimed to investigate the association of vacA s, m, i, and d regions with the risk of atrophic gastritis and intestinal metaplasia in a Casablanca population. Methodology: A total of 210 patients suffering from gastric lesions (chronic gastritis, atrophic gastritis, and intestinal metaplasia) were enrolled. The type of lesion was diagnosed by histological examination. Detection of H. pylori infection and genotyping of vacA regions were carried out by PCR. Results: The prevalence of H. pylori was 95%. The most common vacA genotypes were s2 (51.5%), m2 (77%), i2 (60.5%), and d2 (58.5%). VacA s1, m1, and i1 genotypes were associated with a high risk of intestinal metaplasia, while the vacA d1 genotype increases the risk of atrophic gastritis and intestinal metaplasia. The most common vacA combination was s2/m2/i2/d2 (52%), and it was more detected in chronic gastritis. The moderate virulent vacA combination (s1/m2/i1/d1) increases the risk of atrophic gastritis, while the most virulent vacA combination (s1/m1/i1/d1) increases the risk of intestinal metaplasia. Conclusions: Genotyping of vacA d region might be a reliable marker for the identification of vacA virulent strains that represent a high risk of developing precancerous lesions (atrophic gastritis and intestinal metaplasia). |
| doi_str_mv | 10.3855/jidc.14435 |
| format | Article |
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The vacA gene is one of the most virulence factors of H. pylori and genetic diversity in its s, m, i, and d regions is associated with gastric lesions severity. This study aimed to investigate the association of vacA s, m, i, and d regions with the risk of atrophic gastritis and intestinal metaplasia in a Casablanca population. Methodology: A total of 210 patients suffering from gastric lesions (chronic gastritis, atrophic gastritis, and intestinal metaplasia) were enrolled. The type of lesion was diagnosed by histological examination. Detection of H. pylori infection and genotyping of vacA regions were carried out by PCR. Results: The prevalence of H. pylori was 95%. The most common vacA genotypes were s2 (51.5%), m2 (77%), i2 (60.5%), and d2 (58.5%). VacA s1, m1, and i1 genotypes were associated with a high risk of intestinal metaplasia, while the vacA d1 genotype increases the risk of atrophic gastritis and intestinal metaplasia. The most common vacA combination was s2/m2/i2/d2 (52%), and it was more detected in chronic gastritis. The moderate virulent vacA combination (s1/m2/i1/d1) increases the risk of atrophic gastritis, while the most virulent vacA combination (s1/m1/i1/d1) increases the risk of intestinal metaplasia. Conclusions: Genotyping of vacA d region might be a reliable marker for the identification of vacA virulent strains that represent a high risk of developing precancerous lesions (atrophic gastritis and intestinal metaplasia).</description><identifier>ISSN: 1972-2680</identifier><identifier>ISSN: 2036-6590</identifier><identifier>EISSN: 1972-2680</identifier><identifier>DOI: 10.3855/jidc.14435</identifier><identifier>PMID: 34516420</identifier><language>eng</language><publisher>TRAMANIGLIO: J Infection Developing Countries</publisher><subject>Adult ; Aged ; Bacterial infections ; Bacterial Proteins - isolation & purification ; Bacterial Proteins - metabolism ; Biomarkers - analysis ; Biopsy ; Cancer ; DNA polymerase ; Female ; Gastritis, Atrophic - etiology ; Gastroenterology ; Genes ; Genotype ; Genotype & phenotype ; Gram-negative bacteria ; Helicobacter Infections - complications ; Helicobacter Infections - genetics ; Humans ; Infectious Diseases ; Life Sciences & Biomedicine ; Male ; Medical prognosis ; Middle Aged ; Morocco ; Peptides ; Polymorphism, Genetic ; Population ; Precancerous Conditions - etiology ; Risk factors ; Science & Technology ; Virulence ; Virulence Factors - genetics</subject><ispartof>Journal of infection in developing countries, 2021-08, Vol.15 (8), p.1124-1132</ispartof><rights>Copyright (c) 2021 Mohamed Reda Jouimyi, Ghizlane Bounder, Imane Essaidi, Hasna Boura, Wafaa Badre, Hakima Benomar, Khalid Zerouali, Halima Lebrazi, Anass Kettani, Fatima Maachi.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000704408000013</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c315t-f33ac90aaf58c51d1af517e699e73816cf85f6ac79e56cd5899e25722f4a479e3</citedby><cites>FETCH-LOGICAL-c315t-f33ac90aaf58c51d1af517e699e73816cf85f6ac79e56cd5899e25722f4a479e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929,39262</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34516420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jouimyi, Mohamed Reda</creatorcontrib><creatorcontrib>Bounder, Ghizlane</creatorcontrib><creatorcontrib>Essaidi, Imane</creatorcontrib><creatorcontrib>Boura, Hasna</creatorcontrib><creatorcontrib>Badre, Wafaa</creatorcontrib><creatorcontrib>Benomar, Hakima</creatorcontrib><creatorcontrib>Zerouali, Khalid</creatorcontrib><creatorcontrib>Lebrazi, Halima</creatorcontrib><creatorcontrib>Kettani, Anass</creatorcontrib><creatorcontrib>Maachi, Fatima</creatorcontrib><title>Association of Helicobacter pylori vacA polymorphisms with the risk of gastric precancerous lesions in a Moroccan population</title><title>Journal of infection in developing countries</title><addtitle>J INFECT DEV COUNTR</addtitle><addtitle>J Infect Dev Ctries</addtitle><description>Introduction: Helicobacter pylori infection is the major risk factor of atrophic gastritis and intestinal metaplasia. The vacA gene is one of the most virulence factors of H. pylori and genetic diversity in its s, m, i, and d regions is associated with gastric lesions severity. This study aimed to investigate the association of vacA s, m, i, and d regions with the risk of atrophic gastritis and intestinal metaplasia in a Casablanca population. Methodology: A total of 210 patients suffering from gastric lesions (chronic gastritis, atrophic gastritis, and intestinal metaplasia) were enrolled. The type of lesion was diagnosed by histological examination. Detection of H. pylori infection and genotyping of vacA regions were carried out by PCR. Results: The prevalence of H. pylori was 95%. The most common vacA genotypes were s2 (51.5%), m2 (77%), i2 (60.5%), and d2 (58.5%). VacA s1, m1, and i1 genotypes were associated with a high risk of intestinal metaplasia, while the vacA d1 genotype increases the risk of atrophic gastritis and intestinal metaplasia. The most common vacA combination was s2/m2/i2/d2 (52%), and it was more detected in chronic gastritis. The moderate virulent vacA combination (s1/m2/i1/d1) increases the risk of atrophic gastritis, while the most virulent vacA combination (s1/m1/i1/d1) increases the risk of intestinal metaplasia. Conclusions: Genotyping of vacA d region might be a reliable marker for the identification of vacA virulent strains that represent a high risk of developing precancerous lesions (atrophic gastritis and intestinal metaplasia).</description><subject>Adult</subject><subject>Aged</subject><subject>Bacterial infections</subject><subject>Bacterial Proteins - isolation & purification</subject><subject>Bacterial Proteins - metabolism</subject><subject>Biomarkers - analysis</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>DNA polymerase</subject><subject>Female</subject><subject>Gastritis, Atrophic - etiology</subject><subject>Gastroenterology</subject><subject>Genes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Gram-negative bacteria</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - genetics</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Morocco</subject><subject>Peptides</subject><subject>Polymorphism, Genetic</subject><subject>Population</subject><subject>Precancerous Conditions - etiology</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>Virulence</subject><subject>Virulence Factors - genetics</subject><issn>1972-2680</issn><issn>2036-6590</issn><issn>1972-2680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkU-P0zAQxS0EYv_AhQ-ALHFBi7rYsZ04x6oCFmkRFzhH7nRMXZI4eBxWlfjwuO2yQpw4-cnzmzejeYy9kOJaWWPe7sIGrqXWyjxi57JtqkVVW_H4L33GLoh2QphWGfmUnSltZK0rcc5-LYkiBJdDHHn0_Ab7AHHtIGPi076PKfCfDpZ8iv1-iGnaBhqI34W85XmLPAX6fuj75iinAHxKCG4ETHEm3iMVW-Jh5I5_iilCqRWnae6PA5-xJ971hM_v30v29f27L6ubxe3nDx9Xy9sFKGnywivloBXOeWPByI0sQjZYty02ysoavDW-dtC0aGrYGFsKlWmqymuny6e6ZK9PvlOKP2ak3A2BAPvejVj27A6wUVLVbUFf_YPu4pzGst2JkpWVulBXJwpSJErouymFwaV9J0V3yKQ7ZNIdMynwy3vLeT3g5gH9E0IB7Am4w3X0BAHLAR8wIUQjtBa2CCHVKuTj7VZxHnNpffP_reo3QbCp0Q</recordid><startdate>20210831</startdate><enddate>20210831</enddate><creator>Jouimyi, Mohamed Reda</creator><creator>Bounder, Ghizlane</creator><creator>Essaidi, Imane</creator><creator>Boura, Hasna</creator><creator>Badre, Wafaa</creator><creator>Benomar, Hakima</creator><creator>Zerouali, Khalid</creator><creator>Lebrazi, Halima</creator><creator>Kettani, Anass</creator><creator>Maachi, Fatima</creator><general>J Infection Developing Countries</general><general>Journal of Infection in Developing Countries</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8C1</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210831</creationdate><title>Association of Helicobacter pylori vacA polymorphisms with the risk of gastric precancerous lesions in a Moroccan population</title><author>Jouimyi, Mohamed Reda ; 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The vacA gene is one of the most virulence factors of H. pylori and genetic diversity in its s, m, i, and d regions is associated with gastric lesions severity. This study aimed to investigate the association of vacA s, m, i, and d regions with the risk of atrophic gastritis and intestinal metaplasia in a Casablanca population. Methodology: A total of 210 patients suffering from gastric lesions (chronic gastritis, atrophic gastritis, and intestinal metaplasia) were enrolled. The type of lesion was diagnosed by histological examination. Detection of H. pylori infection and genotyping of vacA regions were carried out by PCR. Results: The prevalence of H. pylori was 95%. The most common vacA genotypes were s2 (51.5%), m2 (77%), i2 (60.5%), and d2 (58.5%). VacA s1, m1, and i1 genotypes were associated with a high risk of intestinal metaplasia, while the vacA d1 genotype increases the risk of atrophic gastritis and intestinal metaplasia. The most common vacA combination was s2/m2/i2/d2 (52%), and it was more detected in chronic gastritis. The moderate virulent vacA combination (s1/m2/i1/d1) increases the risk of atrophic gastritis, while the most virulent vacA combination (s1/m1/i1/d1) increases the risk of intestinal metaplasia. Conclusions: Genotyping of vacA d region might be a reliable marker for the identification of vacA virulent strains that represent a high risk of developing precancerous lesions (atrophic gastritis and intestinal metaplasia).</abstract><cop>TRAMANIGLIO</cop><pub>J Infection Developing Countries</pub><pmid>34516420</pmid><doi>10.3855/jidc.14435</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Bacterial infections Bacterial Proteins - isolation & purification Bacterial Proteins - metabolism Biomarkers - analysis Biopsy Cancer DNA polymerase Female Gastritis, Atrophic - etiology Gastroenterology Genes Genotype Genotype & phenotype Gram-negative bacteria Helicobacter Infections - complications Helicobacter Infections - genetics Humans Infectious Diseases Life Sciences & Biomedicine Male Medical prognosis Middle Aged Morocco Peptides Polymorphism, Genetic Population Precancerous Conditions - etiology Risk factors Science & Technology Virulence Virulence Factors - genetics |
| title | Association of Helicobacter pylori vacA polymorphisms with the risk of gastric precancerous lesions in a Moroccan population |
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