Behcet's Disease with Extremely High Levels of Urinary beta 2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment

Behcet's disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behcet's disease who showed an extremely high level of urinary beta 2-microglulin, which is one of the markers of renal dysfunction, despite normal serum creatinine levels. The patient was on non-steroidal anti-inflammatory drug (NSAID) therapy for 7 weeks, and this could have affected his renal dysfunction. The present report suggests that renal injury should not be underestimated in patients with Behcet's disease, especially in patients using NSAIDs.