Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability

Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability

Breast Cancer gene 1 (BRCA1) is a large, multifunctional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nucleus. Here, we propose BRCA1 expression is critical for the...

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Veröffentlicht in:Exercise and sport sciences reviews 2021-10, Vol.49 (4), p.267-273
Hauptverfasser: Tarpey, Michael D., Amorese, Adam J., LaFave, Elizabeth R., Minchew, Everett C., Fisher-Wellman, Kelsey H., McClung, Joseph M., Hvastkovs, Eli G., Spangenburg, Espen E.
Format: Artikel
Sprache:eng
Schlagworte:
BRCA1 Protein - genetics
BRCA1 Protein - metabolism
Breast Neoplasms - genetics
Female
Genomic Instability
Humans
Mitochondria
Muscle, Skeletal - metabolism
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Zusammenfassung:Breast Cancer gene 1 (BRCA1) is a large, multifunctional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nucleus. Here, we propose BRCA1 expression is critical for the maintenance of force production and mitochondrial respiration in skeletal muscle.
ISSN:0091-6331
1538-3008
DOI:10.1249/JES.0000000000000265