Subclinical cardiovascular disease and risk of incident frailty: The British Regional Heart Study

Subclinical cardiovascular disease and risk of incident frailty: The British Regional Heart Study

Subclinical cardiovascular disease (CVD) is cross-sectionally associated with frailty, but the relationship between subclinical CVD and incident frailty has not been reported. We aimed to assess this prospective association. Longitudinal analysis of data from the British Regional Heart Study, a pros...

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Veröffentlicht in:Experimental gerontology 2021-10, Vol.154, p.111522-111522, Article 111522
Hauptverfasser: McKechnie, Douglas G.J., Papacosta, A. Olia, Lennon, Lucy T., Ellins, Elizabeth A., Halcox, Julian P.J., Ramsay, Sheena E., Whincup, Peter H., Wannamethee, S. Goya
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aging
Atherosclerosis
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Carotid Intima-Media Thickness
Follow-up studies
Frailty
Frailty - diagnosis
Frailty - epidemiology
Geriatrics & Gerontology
Humans
Life Sciences & Biomedicine
Male
Prospective Studies
Pulse Wave Analysis
Risk Factors
Science & Technology
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Zusammenfassung:Subclinical cardiovascular disease (CVD) is cross-sectionally associated with frailty, but the relationship between subclinical CVD and incident frailty has not been reported. We aimed to assess this prospective association. Longitudinal analysis of data from the British Regional Heart Study, a prospective cohort study. 1057 men, aged 71–92 years, robust or pre-frail at baseline, and without a clinical diagnosis of CVD. Participants underwent baseline measurement of carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (CIMT), carotid distensibility coefficient (DC), and ankle-brachial pressure index (ABPI), and had questionnaire-based frailty assessment after three years. Frailty status was based on the Fried phenotype. Multivariate logistic regressions examined associations between incident frailty and tertile of cfPWV, CIMT, DC, and ABPI group (
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2021.111522