Xiaoyu Xiezhuo Drink Protects against Ischemia-Reperfusion Acute Kidney Injury in Aged Mice through Inhibiting the TGF-β1/Smad3 and HIF1 Signaling Pathways

Acute kidney injury (AKI) is responsible for significant mortality among hospitalized patients that is especially troubling aged people. An effective self-made Chinese medicine formula, Xiaoyu Xiezhuo Drink (XXD), displayed therapeutic effects on AKI. However, the compositions and underlying mechani...

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Veröffentlicht in:	BioMed research international 2021-09, Vol.2021, p.1-19, Article 9963732
Hauptverfasser:	Ye, Qingqing, Chen, Hongbo, Ma, Hongzhen, Xiang, Xiaojun, Hu, Shouci, Xia, Cong, Fu, Lanjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animal models Bioinformatics Biotechnology & Applied Microbiology Cell cycle Chemical compounds Chinese medicine Collagen Epidermal growth factor receptors Gelatinase B Genes Herbal medicine High performance liquid chromatography Hydrogen bonds Inflammation Injuries Injury analysis Intercellular adhesion molecule 1 Interleukin 6 Ischemia Kidneys Life Sciences & Biomedicine Liquid chromatography Mass spectrometry Mass spectroscopy Medicine, Research & Experimental Network analysis Older people Oxidative stress p53 Protein Peroxisome proliferator-activated receptors Pharmaceuticals Pharmacology Protein expression Protein interaction Proteins Quadrupoles Renal function Reperfusion Research & Experimental Medicine Science & Technology Senescence Signal transduction Signaling Smad3 protein Smad7 protein Therapeutic targets TLR4 protein Toll-like receptors Tumor necrosis factor-TNF
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