Protocol: Prospective observational study aiming for micro-elimination of hepatitis C virus in Nagawa town: The Nagawa Project
The World Health Organization has set a goal of hepatitis C virus (HCV) elimination by the year 2030. However, no regions in Japan have succeeded in eradicating HCV. Micro-elimination is an approach to attain hepatitis C eradication in which national eradication goals are applied to specific populat...
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| Veröffentlicht in: | PloS one 2021-08, Vol.16 (8), p.e0256711-e0256711 |
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| creator | Kobayashi, Hiroyuki Joshita, Satoru Akahane, Yuki Matsuzaki, Katsuhiko Yamada, Hiromi Aomura, Daiki Joshita, Nao Midorikawa, Hajime Suyama, Kazuhiro Ota, Masao Wakabayashi, Shun-Ichi Yamashita, Yuki Sugiura, Ayumi Yamazaki, Tomoo Misawa, Hiromichi Umemura, Takeji |
| description | The World Health Organization has set a goal of hepatitis C virus (HCV) elimination by the year 2030. However, no regions in Japan have succeeded in eradicating HCV. Micro-elimination is an approach to attain hepatitis C eradication in which national eradication goals are applied to specific populations so that viral treatment and control efforts can move forward quickly and efficiently. In order to eradicate HCV from Japan, this study aims to achieve HCV micro-elimination in the town of Nagawa.
The Nagawa Project is an ongoing, prospective, multiple-institution, observational study running from April 1, 2021, to March 31, 2024. All residents of Nagawa town, excluding those under 20 years of age, not consenting to the study, or unable to undergo health check-ups due to nursing care needs, will be included. If found to be HCV antibody-positive, the participant will be recommended to see a doctor in consideration of MAC-2 binding protein glycosylation isomer values. Then, the participant will undergo serum HCV RNA measurement with the real-time polymerase chain reaction by an attending physician. If the participant is HCV RNA-positive, he or she will be referred to a hepatologist for further evaluation. In the case of a definitive diagnosis of chronic hepatitis C, direct acting antiviral treatment will be initiated. Through this process, HCV will be systematically micro-eliminated from the region.
The Nagawa Project will reveal the prevalence of chronic HCV in addition to the HCV eradication rate in Nagawa town towards achieving HCV micro-elimination.
This study is performed by Shinshu University School of Medicine and was registered as UMIN 000044114 on May 6, 2021. |
| doi_str_mv | 10.1371/journal.pone.0256711 |
| format | Article |
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The Nagawa Project is an ongoing, prospective, multiple-institution, observational study running from April 1, 2021, to March 31, 2024. All residents of Nagawa town, excluding those under 20 years of age, not consenting to the study, or unable to undergo health check-ups due to nursing care needs, will be included. If found to be HCV antibody-positive, the participant will be recommended to see a doctor in consideration of MAC-2 binding protein glycosylation isomer values. Then, the participant will undergo serum HCV RNA measurement with the real-time polymerase chain reaction by an attending physician. If the participant is HCV RNA-positive, he or she will be referred to a hepatologist for further evaluation. In the case of a definitive diagnosis of chronic hepatitis C, direct acting antiviral treatment will be initiated. Through this process, HCV will be systematically micro-eliminated from the region.
The Nagawa Project will reveal the prevalence of chronic HCV in addition to the HCV eradication rate in Nagawa town towards achieving HCV micro-elimination.
This study is performed by Shinshu University School of Medicine and was registered as UMIN 000044114 on May 6, 2021.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0256711</identifier><identifier>PMID: 34437651</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibodies ; Antiviral Agents - therapeutic use ; Asymptomatic ; Biology and life sciences ; Chronic illnesses ; Consent ; Disease Eradication ; Earth Sciences ; Eradication ; Female ; Gastroenterology ; Glycosylation ; Health promotion ; Hepacivirus - pathogenicity ; Hepatitis ; Hepatitis C ; Hepatitis C virus ; Hepatitis C, Chronic - epidemiology ; Hepatitis C, Chronic - prevention & control ; Hepatitis C, Chronic - virology ; Hepatology ; Hospitals ; Humans ; Infections ; Internal medicine ; Japan - epidemiology ; Liver cirrhosis ; Liver diseases ; Male ; Medical diagnosis ; Medical laboratories ; Medicine ; Medicine and health sciences ; Metabolic syndrome ; Observational studies ; People and Places ; Polymerase chain reaction ; Prevention ; Prospective Studies ; Research and Analysis Methods ; Social Sciences ; Study Protocol ; Viruses ; World Health Organization</subject><ispartof>PloS one, 2021-08, Vol.16 (8), p.e0256711-e0256711</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Kobayashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Kobayashi et al 2021 Kobayashi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d833e45a485ae38fea8b225f94e072df45f352bc4359911dccf756f05f0cb3833</citedby><cites>FETCH-LOGICAL-c692t-d833e45a485ae38fea8b225f94e072df45f352bc4359911dccf756f05f0cb3833</cites><orcidid>0000-0002-6364-9654 ; 0000-0002-6400-5658 ; 0000-0002-6313-5549 ; 0000-0001-7985-919X ; 0000-0002-0162-4208 ; 0000-0001-5427-7628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389441/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389441/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34437651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chuang, Wan-Long</contributor><creatorcontrib>Kobayashi, Hiroyuki</creatorcontrib><creatorcontrib>Joshita, Satoru</creatorcontrib><creatorcontrib>Akahane, Yuki</creatorcontrib><creatorcontrib>Matsuzaki, Katsuhiko</creatorcontrib><creatorcontrib>Yamada, Hiromi</creatorcontrib><creatorcontrib>Aomura, Daiki</creatorcontrib><creatorcontrib>Joshita, Nao</creatorcontrib><creatorcontrib>Midorikawa, Hajime</creatorcontrib><creatorcontrib>Suyama, Kazuhiro</creatorcontrib><creatorcontrib>Ota, Masao</creatorcontrib><creatorcontrib>Wakabayashi, Shun-Ichi</creatorcontrib><creatorcontrib>Yamashita, Yuki</creatorcontrib><creatorcontrib>Sugiura, Ayumi</creatorcontrib><creatorcontrib>Yamazaki, Tomoo</creatorcontrib><creatorcontrib>Misawa, Hiromichi</creatorcontrib><creatorcontrib>Umemura, Takeji</creatorcontrib><title>Protocol: Prospective observational study aiming for micro-elimination of hepatitis C virus in Nagawa town: The Nagawa Project</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The World Health Organization has set a goal of hepatitis C virus (HCV) elimination by the year 2030. However, no regions in Japan have succeeded in eradicating HCV. Micro-elimination is an approach to attain hepatitis C eradication in which national eradication goals are applied to specific populations so that viral treatment and control efforts can move forward quickly and efficiently. In order to eradicate HCV from Japan, this study aims to achieve HCV micro-elimination in the town of Nagawa.
The Nagawa Project is an ongoing, prospective, multiple-institution, observational study running from April 1, 2021, to March 31, 2024. All residents of Nagawa town, excluding those under 20 years of age, not consenting to the study, or unable to undergo health check-ups due to nursing care needs, will be included. If found to be HCV antibody-positive, the participant will be recommended to see a doctor in consideration of MAC-2 binding protein glycosylation isomer values. Then, the participant will undergo serum HCV RNA measurement with the real-time polymerase chain reaction by an attending physician. If the participant is HCV RNA-positive, he or she will be referred to a hepatologist for further evaluation. In the case of a definitive diagnosis of chronic hepatitis C, direct acting antiviral treatment will be initiated. Through this process, HCV will be systematically micro-eliminated from the region.
The Nagawa Project will reveal the prevalence of chronic HCV in addition to the HCV eradication rate in Nagawa town towards achieving HCV micro-elimination.
This study is performed by Shinshu University School of Medicine and was registered as UMIN 000044114 on May 6, 2021.</description><subject>Antibodies</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Asymptomatic</subject><subject>Biology and life sciences</subject><subject>Chronic illnesses</subject><subject>Consent</subject><subject>Disease Eradication</subject><subject>Earth Sciences</subject><subject>Eradication</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Glycosylation</subject><subject>Health promotion</subject><subject>Hepacivirus - pathogenicity</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - epidemiology</subject><subject>Hepatitis C, Chronic - prevention & control</subject><subject>Hepatitis C, Chronic - 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Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Hiroyuki</au><au>Joshita, Satoru</au><au>Akahane, Yuki</au><au>Matsuzaki, Katsuhiko</au><au>Yamada, Hiromi</au><au>Aomura, Daiki</au><au>Joshita, Nao</au><au>Midorikawa, Hajime</au><au>Suyama, Kazuhiro</au><au>Ota, Masao</au><au>Wakabayashi, Shun-Ichi</au><au>Yamashita, Yuki</au><au>Sugiura, Ayumi</au><au>Yamazaki, Tomoo</au><au>Misawa, Hiromichi</au><au>Umemura, Takeji</au><au>Chuang, Wan-Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protocol: Prospective observational study aiming for micro-elimination of hepatitis C virus in Nagawa town: The Nagawa Project</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-08-26</date><risdate>2021</risdate><volume>16</volume><issue>8</issue><spage>e0256711</spage><epage>e0256711</epage><pages>e0256711-e0256711</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The World Health Organization has set a goal of hepatitis C virus (HCV) elimination by the year 2030. However, no regions in Japan have succeeded in eradicating HCV. Micro-elimination is an approach to attain hepatitis C eradication in which national eradication goals are applied to specific populations so that viral treatment and control efforts can move forward quickly and efficiently. In order to eradicate HCV from Japan, this study aims to achieve HCV micro-elimination in the town of Nagawa.
The Nagawa Project is an ongoing, prospective, multiple-institution, observational study running from April 1, 2021, to March 31, 2024. All residents of Nagawa town, excluding those under 20 years of age, not consenting to the study, or unable to undergo health check-ups due to nursing care needs, will be included. If found to be HCV antibody-positive, the participant will be recommended to see a doctor in consideration of MAC-2 binding protein glycosylation isomer values. Then, the participant will undergo serum HCV RNA measurement with the real-time polymerase chain reaction by an attending physician. If the participant is HCV RNA-positive, he or she will be referred to a hepatologist for further evaluation. In the case of a definitive diagnosis of chronic hepatitis C, direct acting antiviral treatment will be initiated. Through this process, HCV will be systematically micro-eliminated from the region.
The Nagawa Project will reveal the prevalence of chronic HCV in addition to the HCV eradication rate in Nagawa town towards achieving HCV micro-elimination.
This study is performed by Shinshu University School of Medicine and was registered as UMIN 000044114 on May 6, 2021.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34437651</pmid><doi>10.1371/journal.pone.0256711</doi><tpages>e0256711</tpages><orcidid>https://orcid.org/0000-0002-6364-9654</orcidid><orcidid>https://orcid.org/0000-0002-6400-5658</orcidid><orcidid>https://orcid.org/0000-0002-6313-5549</orcidid><orcidid>https://orcid.org/0000-0001-7985-919X</orcidid><orcidid>https://orcid.org/0000-0002-0162-4208</orcidid><orcidid>https://orcid.org/0000-0001-5427-7628</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-08, Vol.16 (8), p.e0256711-e0256711 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2564929111 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antibodies Antiviral Agents - therapeutic use Asymptomatic Biology and life sciences Chronic illnesses Consent Disease Eradication Earth Sciences Eradication Female Gastroenterology Glycosylation Health promotion Hepacivirus - pathogenicity Hepatitis Hepatitis C Hepatitis C virus Hepatitis C, Chronic - epidemiology Hepatitis C, Chronic - prevention & control Hepatitis C, Chronic - virology Hepatology Hospitals Humans Infections Internal medicine Japan - epidemiology Liver cirrhosis Liver diseases Male Medical diagnosis Medical laboratories Medicine Medicine and health sciences Metabolic syndrome Observational studies People and Places Polymerase chain reaction Prevention Prospective Studies Research and Analysis Methods Social Sciences Study Protocol Viruses World Health Organization |
| title | Protocol: Prospective observational study aiming for micro-elimination of hepatitis C virus in Nagawa town: The Nagawa Project |
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