Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions

Particulate air pollutants are known contributors to global cardiorespiratory mortality through several pathways. We examined the effects of varied exposure to PM2.5 and trace metals on biological markers of airway inflammation, oxidative stress, and hemodynamic function of young individuals living...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Environmental pollution (1987) 2021-11, Vol.288, p.117797-117797, Article 117797
Hauptverfasser: Sabeti, Zahra, Ansarin, Khalil, Seyedrezazadeh, Ensiyeh, Jafarabadi, Mohammad Asghari, Zafari, Venus, Dastgiri, Saeed, Shakerkhatibi, Mohammad, Gholampour, Akbar, Khamnian, Zhila, Sepehri, Maryam, Dahim, Mahin, Sharbafi, Jabraeil, Hakimi, Daryoush
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 117797
container_issue
container_start_page 117797
container_title Environmental pollution (1987)
container_volume 288
creator Sabeti, Zahra
Ansarin, Khalil
Seyedrezazadeh, Ensiyeh
Jafarabadi, Mohammad Asghari
Zafari, Venus
Dastgiri, Saeed
Shakerkhatibi, Mohammad
Gholampour, Akbar
Khamnian, Zhila
Sepehri, Maryam
Dahim, Mahin
Sharbafi, Jabraeil
Hakimi, Daryoush
description Particulate air pollutants are known contributors to global cardiorespiratory mortality through several pathways. We examined the effects of varied exposure to PM2.5 and trace metals on biological markers of airway inflammation, oxidative stress, and hemodynamic function of young individuals living in two different exposure settings. We enrolled and followed a panel of 97 healthy nonsmoking participants aged 15–18 years living in a highly polluted metropolitan city of Tabriz (TBZ) and a much less polluted semi-urban town of Hadishahr (HDS). For five consecutive months, the subjects were examined by a physician, and fractional exhaled nitric oxide levels (FENO) were measured. Samples of exhaled breath condensation (EBC) were obtained for measuring interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and total nitric oxide (NOx). We measured daily outdoor PM2.5 mass concentration in a fixed station in each location for all this period. The PM-metal content was analyzed by ICP-MS. The linear mixed-effects regression models were applied for data analysis. The averages of PM2.5 mass and total metals in TBZ were nearly two and four times higher than in HDS, respectively. In TBZ, an increased IQR of PM2.5 mass during 0–5 days was -correlated with a significant rise in diastolic blood pressure, heart rate, TNF-α, FENO, and NOx and reduction of IL-6. Moreover, exposure to low PM2.5 concentration is significantly -correlated with an elevation in diastolic blood pressure in HDS. We also observed that exposure to metal constituents in the highly polluted region is correlated with increased TNF-α and IL-6 with 131.80% (95% CI: 56.01, 244.39) and 47.51% (95% CI: 33.01, 62.05) per IQR of Hg, respectively. This study suggests that exposure to ambient PM2.5 and their metal contents in highly polluted areas may incite significant changes in airway inflammation, oxidative stress, and hemodynamic parameters in healthy subjects. [Display omitted] •Various noninvasive biomarkers were investigated in an associated pathway.•PM-metals was four times higher in the polluted city than in the control city.•EBC NOx and hemodynamic responses decreased with transition metal exposure.•Exposure to PM2.5 and metals may elevate airway inflammatory markers in polluted city.•Even exposure to PM2.5 below the WHO limits can raised NO-metabolism.
doi_str_mv 10.1016/j.envpol.2021.117797
format Article
fullrecord <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000697022600003CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0269749121013798</els_id><sourcerecordid>2557223511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-770077146560cbeed018ecf9aed076e5a90ac80fda7507ff134bf502dd3974b43</originalsourceid><addsrcrecordid>eNqNUcuOEzEQHCEQGxb-gIOPSOwEv2ac4YAURbykRXCAs-XYPYmDxw62J2F-la_B2VnBDXFyq13VXV1VVc8JXhJM2leHJfjTMbglxZQsCRGiEw-qBVkJVrec8ofVAtO2qwXvyFX1JKUDxpgzxh5XV4wz2uGGL6pfaz1mQBHSMfgECYUeKRvPakLhpzUq2xOglMt_ukHW904NQ2kGf4OUN2gPQzCTV4PVaFDxO8SEckBq2FrwGX35RJfNHTDvwUaUo9KABsjKIR18LphUwMHvyiTl8n5CygQHSYPXkF6jNToqD64oGM1U9qO93e3dhMrdrug26FQ2jgm5cP7bi7ArAtPT6lGvXIJn9-919e3d26-bD_Xt5_cfN-vbWjPW5VoIjIUgvG1arLcABpMV6L5TpRItNKrDSq9wb5RosOh7wvi2bzA1hnWCbzm7rl7Mc48x_BghZTnYcoBzRXkYk6RNIyhlDSEFymeojiGlCL08Rlt8myTB8pKqPMg5VXlJVc6pFtrLmXaGbeiTthd3_lBLrG0nMKVtqTAr6NX_ozc238W5CaPPhfpmpkLx62Qhynu6sRF0libYfyv9DZAo0dc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2557223511</pqid></control><display><type>article</type><title>Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions</title><source>Elsevier ScienceDirect Journals Complete</source><source>Web of Science - Science Citation Index Expanded - 2021&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><creator>Sabeti, Zahra ; Ansarin, Khalil ; Seyedrezazadeh, Ensiyeh ; Jafarabadi, Mohammad Asghari ; Zafari, Venus ; Dastgiri, Saeed ; Shakerkhatibi, Mohammad ; Gholampour, Akbar ; Khamnian, Zhila ; Sepehri, Maryam ; Dahim, Mahin ; Sharbafi, Jabraeil ; Hakimi, Daryoush</creator><creatorcontrib>Sabeti, Zahra ; Ansarin, Khalil ; Seyedrezazadeh, Ensiyeh ; Jafarabadi, Mohammad Asghari ; Zafari, Venus ; Dastgiri, Saeed ; Shakerkhatibi, Mohammad ; Gholampour, Akbar ; Khamnian, Zhila ; Sepehri, Maryam ; Dahim, Mahin ; Sharbafi, Jabraeil ; Hakimi, Daryoush</creatorcontrib><description>Particulate air pollutants are known contributors to global cardiorespiratory mortality through several pathways. We examined the effects of varied exposure to PM2.5 and trace metals on biological markers of airway inflammation, oxidative stress, and hemodynamic function of young individuals living in two different exposure settings. We enrolled and followed a panel of 97 healthy nonsmoking participants aged 15–18 years living in a highly polluted metropolitan city of Tabriz (TBZ) and a much less polluted semi-urban town of Hadishahr (HDS). For five consecutive months, the subjects were examined by a physician, and fractional exhaled nitric oxide levels (FENO) were measured. Samples of exhaled breath condensation (EBC) were obtained for measuring interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and total nitric oxide (NOx). We measured daily outdoor PM2.5 mass concentration in a fixed station in each location for all this period. The PM-metal content was analyzed by ICP-MS. The linear mixed-effects regression models were applied for data analysis. The averages of PM2.5 mass and total metals in TBZ were nearly two and four times higher than in HDS, respectively. In TBZ, an increased IQR of PM2.5 mass during 0–5 days was -correlated with a significant rise in diastolic blood pressure, heart rate, TNF-α, FENO, and NOx and reduction of IL-6. Moreover, exposure to low PM2.5 concentration is significantly -correlated with an elevation in diastolic blood pressure in HDS. We also observed that exposure to metal constituents in the highly polluted region is correlated with increased TNF-α and IL-6 with 131.80% (95% CI: 56.01, 244.39) and 47.51% (95% CI: 33.01, 62.05) per IQR of Hg, respectively. This study suggests that exposure to ambient PM2.5 and their metal contents in highly polluted areas may incite significant changes in airway inflammation, oxidative stress, and hemodynamic parameters in healthy subjects. [Display omitted] •Various noninvasive biomarkers were investigated in an associated pathway.•PM-metals was four times higher in the polluted city than in the control city.•EBC NOx and hemodynamic responses decreased with transition metal exposure.•Exposure to PM2.5 and metals may elevate airway inflammatory markers in polluted city.•Even exposure to PM2.5 below the WHO limits can raised NO-metabolism.</description><identifier>ISSN: 0269-7491</identifier><identifier>EISSN: 1873-6424</identifier><identifier>DOI: 10.1016/j.envpol.2021.117797</identifier><identifier>PMID: 34329054</identifier><language>eng</language><publisher>OXFORD: Elsevier Ltd</publisher><subject>Blood pressure ; Environmental Sciences ; Environmental Sciences &amp; Ecology ; Exhaled breath condensate ; Inflammation markers ; Life Sciences &amp; Biomedicine ; Nitric oxide pathway ; Particulate matter ; Science &amp; Technology</subject><ispartof>Environmental pollution (1987), 2021-11, Vol.288, p.117797-117797, Article 117797</ispartof><rights>2021 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>18</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000697022600003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c339t-770077146560cbeed018ecf9aed076e5a90ac80fda7507ff134bf502dd3974b43</citedby><cites>FETCH-LOGICAL-c339t-770077146560cbeed018ecf9aed076e5a90ac80fda7507ff134bf502dd3974b43</cites><orcidid>0000-0001-5783-5218 ; 0000-0003-1651-6100</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envpol.2021.117797$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,39265,46002</link.rule.ids></links><search><creatorcontrib>Sabeti, Zahra</creatorcontrib><creatorcontrib>Ansarin, Khalil</creatorcontrib><creatorcontrib>Seyedrezazadeh, Ensiyeh</creatorcontrib><creatorcontrib>Jafarabadi, Mohammad Asghari</creatorcontrib><creatorcontrib>Zafari, Venus</creatorcontrib><creatorcontrib>Dastgiri, Saeed</creatorcontrib><creatorcontrib>Shakerkhatibi, Mohammad</creatorcontrib><creatorcontrib>Gholampour, Akbar</creatorcontrib><creatorcontrib>Khamnian, Zhila</creatorcontrib><creatorcontrib>Sepehri, Maryam</creatorcontrib><creatorcontrib>Dahim, Mahin</creatorcontrib><creatorcontrib>Sharbafi, Jabraeil</creatorcontrib><creatorcontrib>Hakimi, Daryoush</creatorcontrib><title>Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions</title><title>Environmental pollution (1987)</title><addtitle>ENVIRON POLLUT</addtitle><description>Particulate air pollutants are known contributors to global cardiorespiratory mortality through several pathways. We examined the effects of varied exposure to PM2.5 and trace metals on biological markers of airway inflammation, oxidative stress, and hemodynamic function of young individuals living in two different exposure settings. We enrolled and followed a panel of 97 healthy nonsmoking participants aged 15–18 years living in a highly polluted metropolitan city of Tabriz (TBZ) and a much less polluted semi-urban town of Hadishahr (HDS). For five consecutive months, the subjects were examined by a physician, and fractional exhaled nitric oxide levels (FENO) were measured. Samples of exhaled breath condensation (EBC) were obtained for measuring interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and total nitric oxide (NOx). We measured daily outdoor PM2.5 mass concentration in a fixed station in each location for all this period. The PM-metal content was analyzed by ICP-MS. The linear mixed-effects regression models were applied for data analysis. The averages of PM2.5 mass and total metals in TBZ were nearly two and four times higher than in HDS, respectively. In TBZ, an increased IQR of PM2.5 mass during 0–5 days was -correlated with a significant rise in diastolic blood pressure, heart rate, TNF-α, FENO, and NOx and reduction of IL-6. Moreover, exposure to low PM2.5 concentration is significantly -correlated with an elevation in diastolic blood pressure in HDS. We also observed that exposure to metal constituents in the highly polluted region is correlated with increased TNF-α and IL-6 with 131.80% (95% CI: 56.01, 244.39) and 47.51% (95% CI: 33.01, 62.05) per IQR of Hg, respectively. This study suggests that exposure to ambient PM2.5 and their metal contents in highly polluted areas may incite significant changes in airway inflammation, oxidative stress, and hemodynamic parameters in healthy subjects. [Display omitted] •Various noninvasive biomarkers were investigated in an associated pathway.•PM-metals was four times higher in the polluted city than in the control city.•EBC NOx and hemodynamic responses decreased with transition metal exposure.•Exposure to PM2.5 and metals may elevate airway inflammatory markers in polluted city.•Even exposure to PM2.5 below the WHO limits can raised NO-metabolism.</description><subject>Blood pressure</subject><subject>Environmental Sciences</subject><subject>Environmental Sciences &amp; Ecology</subject><subject>Exhaled breath condensate</subject><subject>Inflammation markers</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>Nitric oxide pathway</subject><subject>Particulate matter</subject><subject>Science &amp; Technology</subject><issn>0269-7491</issn><issn>1873-6424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNUcuOEzEQHCEQGxb-gIOPSOwEv2ac4YAURbykRXCAs-XYPYmDxw62J2F-la_B2VnBDXFyq13VXV1VVc8JXhJM2leHJfjTMbglxZQsCRGiEw-qBVkJVrec8ofVAtO2qwXvyFX1JKUDxpgzxh5XV4wz2uGGL6pfaz1mQBHSMfgECYUeKRvPakLhpzUq2xOglMt_ukHW904NQ2kGf4OUN2gPQzCTV4PVaFDxO8SEckBq2FrwGX35RJfNHTDvwUaUo9KABsjKIR18LphUwMHvyiTl8n5CygQHSYPXkF6jNToqD64oGM1U9qO93e3dhMrdrug26FQ2jgm5cP7bi7ArAtPT6lGvXIJn9-919e3d26-bD_Xt5_cfN-vbWjPW5VoIjIUgvG1arLcABpMV6L5TpRItNKrDSq9wb5RosOh7wvi2bzA1hnWCbzm7rl7Mc48x_BghZTnYcoBzRXkYk6RNIyhlDSEFymeojiGlCL08Rlt8myTB8pKqPMg5VXlJVc6pFtrLmXaGbeiTthd3_lBLrG0nMKVtqTAr6NX_ozc238W5CaPPhfpmpkLx62Qhynu6sRF0libYfyv9DZAo0dc</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Sabeti, Zahra</creator><creator>Ansarin, Khalil</creator><creator>Seyedrezazadeh, Ensiyeh</creator><creator>Jafarabadi, Mohammad Asghari</creator><creator>Zafari, Venus</creator><creator>Dastgiri, Saeed</creator><creator>Shakerkhatibi, Mohammad</creator><creator>Gholampour, Akbar</creator><creator>Khamnian, Zhila</creator><creator>Sepehri, Maryam</creator><creator>Dahim, Mahin</creator><creator>Sharbafi, Jabraeil</creator><creator>Hakimi, Daryoush</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5783-5218</orcidid><orcidid>https://orcid.org/0000-0003-1651-6100</orcidid></search><sort><creationdate>20211101</creationdate><title>Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions</title><author>Sabeti, Zahra ; Ansarin, Khalil ; Seyedrezazadeh, Ensiyeh ; Jafarabadi, Mohammad Asghari ; Zafari, Venus ; Dastgiri, Saeed ; Shakerkhatibi, Mohammad ; Gholampour, Akbar ; Khamnian, Zhila ; Sepehri, Maryam ; Dahim, Mahin ; Sharbafi, Jabraeil ; Hakimi, Daryoush</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-770077146560cbeed018ecf9aed076e5a90ac80fda7507ff134bf502dd3974b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood pressure</topic><topic>Environmental Sciences</topic><topic>Environmental Sciences &amp; Ecology</topic><topic>Exhaled breath condensate</topic><topic>Inflammation markers</topic><topic>Life Sciences &amp; Biomedicine</topic><topic>Nitric oxide pathway</topic><topic>Particulate matter</topic><topic>Science &amp; Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabeti, Zahra</creatorcontrib><creatorcontrib>Ansarin, Khalil</creatorcontrib><creatorcontrib>Seyedrezazadeh, Ensiyeh</creatorcontrib><creatorcontrib>Jafarabadi, Mohammad Asghari</creatorcontrib><creatorcontrib>Zafari, Venus</creatorcontrib><creatorcontrib>Dastgiri, Saeed</creatorcontrib><creatorcontrib>Shakerkhatibi, Mohammad</creatorcontrib><creatorcontrib>Gholampour, Akbar</creatorcontrib><creatorcontrib>Khamnian, Zhila</creatorcontrib><creatorcontrib>Sepehri, Maryam</creatorcontrib><creatorcontrib>Dahim, Mahin</creatorcontrib><creatorcontrib>Sharbafi, Jabraeil</creatorcontrib><creatorcontrib>Hakimi, Daryoush</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental pollution (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabeti, Zahra</au><au>Ansarin, Khalil</au><au>Seyedrezazadeh, Ensiyeh</au><au>Jafarabadi, Mohammad Asghari</au><au>Zafari, Venus</au><au>Dastgiri, Saeed</au><au>Shakerkhatibi, Mohammad</au><au>Gholampour, Akbar</au><au>Khamnian, Zhila</au><au>Sepehri, Maryam</au><au>Dahim, Mahin</au><au>Sharbafi, Jabraeil</au><au>Hakimi, Daryoush</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions</atitle><jtitle>Environmental pollution (1987)</jtitle><stitle>ENVIRON POLLUT</stitle><date>2021-11-01</date><risdate>2021</risdate><volume>288</volume><spage>117797</spage><epage>117797</epage><pages>117797-117797</pages><artnum>117797</artnum><issn>0269-7491</issn><eissn>1873-6424</eissn><abstract>Particulate air pollutants are known contributors to global cardiorespiratory mortality through several pathways. We examined the effects of varied exposure to PM2.5 and trace metals on biological markers of airway inflammation, oxidative stress, and hemodynamic function of young individuals living in two different exposure settings. We enrolled and followed a panel of 97 healthy nonsmoking participants aged 15–18 years living in a highly polluted metropolitan city of Tabriz (TBZ) and a much less polluted semi-urban town of Hadishahr (HDS). For five consecutive months, the subjects were examined by a physician, and fractional exhaled nitric oxide levels (FENO) were measured. Samples of exhaled breath condensation (EBC) were obtained for measuring interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and total nitric oxide (NOx). We measured daily outdoor PM2.5 mass concentration in a fixed station in each location for all this period. The PM-metal content was analyzed by ICP-MS. The linear mixed-effects regression models were applied for data analysis. The averages of PM2.5 mass and total metals in TBZ were nearly two and four times higher than in HDS, respectively. In TBZ, an increased IQR of PM2.5 mass during 0–5 days was -correlated with a significant rise in diastolic blood pressure, heart rate, TNF-α, FENO, and NOx and reduction of IL-6. Moreover, exposure to low PM2.5 concentration is significantly -correlated with an elevation in diastolic blood pressure in HDS. We also observed that exposure to metal constituents in the highly polluted region is correlated with increased TNF-α and IL-6 with 131.80% (95% CI: 56.01, 244.39) and 47.51% (95% CI: 33.01, 62.05) per IQR of Hg, respectively. This study suggests that exposure to ambient PM2.5 and their metal contents in highly polluted areas may incite significant changes in airway inflammation, oxidative stress, and hemodynamic parameters in healthy subjects. [Display omitted] •Various noninvasive biomarkers were investigated in an associated pathway.•PM-metals was four times higher in the polluted city than in the control city.•EBC NOx and hemodynamic responses decreased with transition metal exposure.•Exposure to PM2.5 and metals may elevate airway inflammatory markers in polluted city.•Even exposure to PM2.5 below the WHO limits can raised NO-metabolism.</abstract><cop>OXFORD</cop><pub>Elsevier Ltd</pub><pmid>34329054</pmid><doi>10.1016/j.envpol.2021.117797</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5783-5218</orcidid><orcidid>https://orcid.org/0000-0003-1651-6100</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0269-7491
ispartof Environmental pollution (1987), 2021-11, Vol.288, p.117797-117797, Article 117797
issn 0269-7491
1873-6424
language eng
recordid cdi_webofscience_primary_000697022600003CitationCount
source Elsevier ScienceDirect Journals Complete; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />
subjects Blood pressure
Environmental Sciences
Environmental Sciences & Ecology
Exhaled breath condensate
Inflammation markers
Life Sciences & Biomedicine
Nitric oxide pathway
Particulate matter
Science & Technology
title Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T07%3A06%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20responses%20of%20airway%20oxidative%20stress,%20inflammation,%20and%20hemodynamic%20markers%20to%20ambient%20PM2.5%20and%20their%20trace%20metal%20contents%20among%20healthy%20adolescences:%20A%20panel%20study%20in%20highly%20polluted%20versus%20low%20polluted%20regions&rft.jtitle=Environmental%20pollution%20(1987)&rft.au=Sabeti,%20Zahra&rft.date=2021-11-01&rft.volume=288&rft.spage=117797&rft.epage=117797&rft.pages=117797-117797&rft.artnum=117797&rft.issn=0269-7491&rft.eissn=1873-6424&rft_id=info:doi/10.1016/j.envpol.2021.117797&rft_dat=%3Cproquest_webof%3E2557223511%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2557223511&rft_id=info:pmid/34329054&rft_els_id=S0269749121013798&rfr_iscdi=true