Catalyst-free and multicomponent synthesis of 3-aminoalkylated indoles via a Mannich-type reaction: multitargeted anticancer, tyrosinase and alpha-glucosidase inhibitory activities

A highly efficient and sustainable approach for the multi-component synthesis of 3-aminoalkylated indoles was investigated via a Mannich-type reaction under catalyst-free conditions, with methanol and ethylene glycol (EG) as the promoting media. Synthesizing various substrates without using column c...

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Veröffentlicht in:	New journal of chemistry 2021-10, Vol.45 (38), p.18183-18191
Hauptverfasser:	Huynh, Thi-Kim-Chi, Ngo, Kim-Khanh-Huy, Nguyen, Hoang-Phuc, Dang, Hoai-Khanh, Phung, Van-Trung, Thai, Khac-Minh, Hoang, Thi-Kim-Dung
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Binding sites Cancer Catalysts Chemical synthesis Chemistry Chemistry, Multidisciplinary Column chromatography Ethylene glycol Glucosidase Hydrogen bonding Hydrophobicity Indoles Molecular docking Physical Sciences Science & Technology Spectrum analysis Substrates Tyrosinase
Online-Zugang:	Volltext
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