PPAR-γ activation enhances myelination and neurological recovery in premature rabbits with intraventricular hemorrhage

Intraventricular hemorrhage (IVH) results in periventricular inflammation, hypomyelination of the white matter, and hydrocephalus in premature infants. No effective therapy exists to prevent these disorders. Peroxisome proliferator activated receptor-γ (PPAR-γ) agonists reduce inflammation, alleviat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-09, Vol.118 (36), p.1-12, Article 2103084118
Hauptverfasser:	Krishna, Sunil, Cheng, Bokun, Sharma, Deep R., Yadav, Sunita, Stempinski, Erin S., Mamtani, Sahil, Shah, Elisa, Deo, Anjali, Acherjee, Trishna, Thomas, Teena, Zhang, Xusheng, Zhang, Jinghang, Iacobas, Dumitru A., Ballabh, Praveen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine monophosphate Agonists Amino Acid Transport Systems, Acidic - deficiency Amino Acid Transport Systems, Acidic - metabolism Amyotrophic lateral sclerosis Animals Animals, Newborn Antioxidants Antiporters - deficiency Antiporters - metabolism Autopsies Autopsy Biological Sciences Cell activation Cerebral Intraventricular Hemorrhage - metabolism Cerebral Intraventricular Hemorrhage - pathology Cyclic AMP Cytokines Disease Models, Animal Down-regulation Erythrocytes Free radicals Gene regulation Gene sequencing Genes Glial stem cells Hemorrhage Hereditary Central Nervous System Demyelinating Diseases - metabolism Humans Hydrocephalus Infant, Premature Infants Inflammation Microglia Microglia - metabolism Mitochondrial Diseases - metabolism Movement disorders Multidisciplinary Sciences Myelin Proteins - biosynthesis Myelination Neonates Neurodegenerative diseases Oligodendroglia - pathology Parkinson's disease Peroxisome proliferator-activated receptors Phagocytosis PPAR gamma - agonists PPAR gamma - metabolism Premature babies Premature birth Psychomotor Disorders - metabolism Rabbits Recovery Rosiglitazone - pharmacology Science & Technology Science & Technology - Other Topics Sequence Analysis, RNA - methods Substantia alba Transcriptomics
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