Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways
Chemotherapy-induced intestinal mucositis, a painful debilitating condition affecting up to 40-100% of patients undergoing chemotherapy, can reduce the patients' quality of life, add health care costs and even postpone cancer treatment. In recent years, the relationships between intestinal micr...
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| Veröffentlicht in: | International journal of molecular sciences 2021-09, Vol.22 (17), p.9474, Article 9474 |
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| description | Chemotherapy-induced intestinal mucositis, a painful debilitating condition affecting up to 40-100% of patients undergoing chemotherapy, can reduce the patients' quality of life, add health care costs and even postpone cancer treatment. In recent years, the relationships between intestinal microbiota dysbiosis and mucositis have drawn much attention in mucositis research. Chemotherapy can shape intestinal microbiota, which, in turn, can aggravate the mucositis through toll-like receptor (TLR) signaling pathways, leading to an increased expression of inflammatory mediators and elevated epithelial cell apoptosis but decreased epithelial cell differentiation and mucosal regeneration. This review summarizes relevant studies related to the relationships of mucositis with chemotherapy regimens, microbiota, TLRs, inflammatory mediators, and intestinal homeostasis, aiming to explore how gut microbiota affects the pathogenesis of mucositis and provides potential new strategies for mucositis alleviation and treatment and development of new therapies. |
| doi_str_mv | 10.3390/ijms22179474 |
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In recent years, the relationships between intestinal microbiota dysbiosis and mucositis have drawn much attention in mucositis research. Chemotherapy can shape intestinal microbiota, which, in turn, can aggravate the mucositis through toll-like receptor (TLR) signaling pathways, leading to an increased expression of inflammatory mediators and elevated epithelial cell apoptosis but decreased epithelial cell differentiation and mucosal regeneration. This review summarizes relevant studies related to the relationships of mucositis with chemotherapy regimens, microbiota, TLRs, inflammatory mediators, and intestinal homeostasis, aiming to explore how gut microbiota affects the pathogenesis of mucositis and provides potential new strategies for mucositis alleviation and treatment and development of new therapies.</description><identifier>ISSN: 1661-6596</identifier><identifier>ISSN: 1422-0067</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22179474</identifier><identifier>PMID: 34502383</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Apoptosis ; Bacteria ; Biochemistry & Molecular Biology ; Cancer therapies ; Cell differentiation ; Chemistry ; Chemistry, Multidisciplinary ; Chemotherapy ; Clinical trials ; Differentiation (biology) ; Dysbacteriosis ; Epithelial cells ; Epithelium ; Experiments ; Health care ; Homeostasis ; Inflammation ; intestinal microbiota dysbiosis ; Intestinal microflora ; Intestine ; Kinases ; Life Sciences & Biomedicine ; Microbiota ; Microorganisms ; Mucosa ; Mucositis ; Pathogenesis ; Patients ; Physical Sciences ; Probiotics ; Quality of life ; Review ; Science & Technology ; Signal transduction ; Toll-like receptors</subject><ispartof>International journal of molecular sciences, 2021-09, Vol.22 (17), p.9474, Article 9474</ispartof><rights>2021 by the authors. 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| subjects | Apoptosis Bacteria Biochemistry & Molecular Biology Cancer therapies Cell differentiation Chemistry Chemistry, Multidisciplinary Chemotherapy Clinical trials Differentiation (biology) Dysbacteriosis Epithelial cells Epithelium Experiments Health care Homeostasis Inflammation intestinal microbiota dysbiosis Intestinal microflora Intestine Kinases Life Sciences & Biomedicine Microbiota Microorganisms Mucosa Mucositis Pathogenesis Patients Physical Sciences Probiotics Quality of life Review Science & Technology Signal transduction Toll-like receptors |
| title | Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways |
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