Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life

Previous studies suggest that parental obesity may adversely impact long-term metabolic health of the offspring. We tested the hypothesis that parental (paternal thorn maternal) obesity impairs cardiac function in the offspring early in life. Within 1-3 days after weaning, offspring from obese rats...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2021-09, Vol.321 (3), p.H485-H495
Hauptverfasser:	do Carmo, Jussara M., Omoto, Ana C. M., Dai, Xuemei, Moak, Sydney P., Mega, Gabriela S., Li, Xuan, Wang, Zhen, Mouton, Alan J., Hall, John E., da Silva, Alexandre A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities ATP Bioenergetics Calcium Calcium (mitochondrial) Calcium ions Calcium signalling Cardiac & Cardiovascular Systems Cardiomyocytes Cardiovascular System & Cardiology Catheterization Echocardiography Electron transport Gender aspects Gender differences Heart High fat diet Insulin Leptin Life Sciences & Biomedicine Males Matrix metalloproteinase Matrix metalloproteinases Metabolism Metalloproteinase Mitochondria Muscle contraction Obesity Offspring Peripheral Vascular Disease Phospholamban Physiology Protein expression Proteins Science & Technology Sex differences Weaning
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