Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival

Adoptively transferred CD19 chimeric antigen receptor (CAR) T cells have led to impressive clinical outcomes in B cell malignancies. Beyond induction of remission, the persistence of CAR-T cells is required to prevent relapse and provide long-term disease control. To improve CAR-T cell function and...

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Veröffentlicht in:	Molecular therapy 2021-09, Vol.29 (9), p.2677-2690
Hauptverfasser:	Julamanee, Jakrawadee, Terakura, Seitaro, Umemura, Koji, Adachi, Yoshitaka, Miyao, Kotaro, Okuno, Shingo, Takagi, Erina, Sakai, Toshiyasu, Koyama, Daisuke, Goto, Tatsunori, Hanajiri, Ryo, Hudecek, Michael, Steinberger, Peter, Leitner, Judith, Nishida, Tetsuya, Murata, Makoto, Kiyoi, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD19 - immunology Biotechnology & Applied Microbiology CD19CAR CD40 CD40 Antigens - metabolism CD79 Antigens - metabolism CD79A Cell Line, Tumor Cell Proliferation chimeric antigen receptor Coculture Techniques gene-modified T cell therapy Genetics & Heredity Humans Immunotherapy, Adoptive intracellular domain modification K562 Cells Life Sciences & Biomedicine Lymphocyte Activation Medicine, Research & Experimental Mice NF-kappa B - metabolism Original Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy Receptors, Chimeric Antigen - metabolism Research & Experimental Medicine Science & Technology signaling domain T cell persistence Treatment Outcome Xenograft Model Antitumor Assays
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