Previous Influenza Infection Exacerbates Allergen Specific Response and Impairs Airway Barrier Integrity in Pre-Sensitized Mice

In this study we assessed the effects of antigen exposure in mice pre-sensitized with allergen following viral infection on changes in lung function, cellular responses and tight junction expression. Female BALB/c mice were sensitized to ovalbumin and infected with influenza A before receiving a sec...

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Veröffentlicht in:	International journal of molecular sciences 2021-08, Vol.22 (16), p.8790, Article 8790
Hauptverfasser:	Looi, Kevin, Larcombe, Alexander N., Perks, Kara L., Berry, Luke J., Zosky, Graeme R., Rigby, Paul, Knight, Darryl A., Kicic, Anthony, Stick, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Allergies Alveoli Antigens Asthma BALB/c mice Biochemistry & Molecular Biology Bronchus Chemistry Chemistry, Multidisciplinary Damping Eosinophils epithelial barrier integrity Epithelium Genotype & phenotype house dust mite Immunoglobulin E Infections Inflammation Influenza Influenza A Leukocytes (eosinophilic) Leukocytes (neutrophilic) Life Sciences & Biomedicine lung function Lungs Methacholine Neutrophils Ovalbumin Pathogens Physical Sciences Respiratory function Respiratory tract Science & Technology tight junctions Viral infections Viruses
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