Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer

Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. The aim of this study was to characterize novel patterns of immune cell infiltration in non‐small cell lung cancer (NSCLC) in relation to its molecular and clinicopathologic characteristics. Lymphocytes (CD...

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Veröffentlicht in:	The Journal of pathology 2021-11, Vol.255 (3), p.243-256
Hauptverfasser:	Backman, Max, La Fleur, Linnéa, Kurppa, Pinja, Djureinovic, Dijana, Elfving, Hedvig, Brunnström, Hans, Mattsson, Johanna Sofia Margareta, Lindberg, Amanda, Pontén, Victor, Eltahir, Mohamed, Mangsbo, Sara, Gulyas, Miklos, Isaksson, Johan, Jirström, Karin, Kärre, Klas, Leandersson, Karin, Mezheyeuski, Artur, Pontén, Fredrik, Strell, Carina, Lindskog, Cecilia, Botling, Johan, Micke, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Cancer and Oncology Cancer och onkologi Carcinoma, Non-Small-Cell Lung - immunology CD163 antigen CD20 antigen CD3 antigen CD4 antigen CD8 antigen checkpoint therapy Clinical Medicine CTLA-4 protein DNA microarrays Female Foxp3 protein Humans immune cell infiltration Immune response (humoral) Immunogenicity Immunotherapy Infiltration Inflammation Innate immunity Killer Cells, Natural - immunology Klinisk medicin Life Sciences & Biomedicine Lung cancer Lung Neoplasms - immunology Lymphocytes B Lymphocytes, Tumor-Infiltrating - immunology Macrophages Male Medical and Health Sciences Medicin och hälsovetenskap Metastases Middle Aged Mutation Non-small cell lung carcinoma NSCLC Oncology p53 Pathology Patologi PD-1 protein PD-L1 PD-L1 protein Phenotypes Plasma Cells Science & Technology Small cell lung carcinoma Transcriptomics Tumor microenvironment Tumor Microenvironment - immunology
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