Why PRP works only on certain patients with tennis elbow? Is PDGFB gene a key for PRP therapy effectiveness? A prospective cohort study
Background There is variability in individual response to platelet-rich plasma (PRP) therapy in tennis elbow treatment. Genetic variation, especially within genes encoding growth factors may influence the observed inter-individual differences. The purpose of this study was to identify polymorphic va...
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| Veröffentlicht in: | BMC musculoskeletal disorders 2021-08, Vol.22 (1), p.710-710, Article 710 |
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| creator | Niemiec, Pawel Szyluk, Karol Balcerzyk, Anna Kalita, Marcin Jarosz, Alicja Iwanicka, Joanna Iwanicki, Tomasz Nowak, Tomasz Negru, Marius Francuz, Tomasz Garczorz, Wojciech Grzeszczak, Wladyslaw Gorczynska-Kosiorz, Sylwia Kania, Wojciech Zak, Iwona |
| description | Background There is variability in individual response to platelet-rich plasma (PRP) therapy in tennis elbow treatment. Genetic variation, especially within genes encoding growth factors may influence the observed inter-individual differences. The purpose of this study was to identify polymorphic variants of the platelet-derived growth factor beta polypeptide gene (PDGFB) that determine an improved individual response to PRP therapy in tennis elbow patients. Methods This prospective cohort study was designed in accordance with STROBE and MIBO guidelines. A cohort of 107 patients (132 elbows, 25 bilateral) was studied, including 65 females (77 elbows) and 42 males (55 elbows), aged 24-64 years (median 46.00 +/- 5.50), with lateral elbow tendinopathy treated with autologous PRP injection. The effectiveness of PRP therapy was recorded in all subjects at 2, 4, 8, 12, 24 and 52 weeks after PRP injection using the Visual Analog Scale (VAS), quick version of Disabilities of the Arm, Shoulder and Hand score (QDASH) and Patient-Rated Tennis Elbow Evaluation (PRTEE). In order to determine the PDGFB variants with the best response to PRP therapy, patient reported outcome measures were compared between individual genotypes within studied polymorphic variants (rs2285099, rs2285097, rs2247128, rs5757572, rs1800817 and rs7289325). The influence of single nucleotide polymorphisms on blood and PRP parameters, including the concentration of PDGF-AB and PDGF-BB proteins was also analyzed. Results Our analysis identified genetic variants of the PDGFB gene that lead to a better response to PRP therapy. The TT (rs2285099) and CC (rs2285097) homozygotes had higher concentration of platelets in whole blood than carriers of other genotypes (p = 0.018) and showed significantly (p < 0.05) lower values of VAS (weeks 2-12), QDASH and PRTEE (weeks 2-24). The rs2285099 and rs2285097 variants formed strong haplotype block (r(2) = 98, D'=100). The AA homozygotes (rs2247128) had significantly lower values of VAS (weeks 4-52), QDASH and PRTEE (weeks 8, 12). Conclusions PDGFB gene's polymorphisms increase the effectiveness of PRP therapy in tennis elbow treatment. Genotyping two polymorphisms of the PDGFB gene, namely rs2285099 (or rs2285097) and rs2247128 may be a helpful diagnostic tool while assessing patients for PRP therapy and modifying the therapy to improve its effectiveness. |
| doi_str_mv | 10.1186/s12891-021-04593-y |
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Is PDGFB gene a key for PRP therapy effectiveness? A prospective cohort study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerNature Journals</source><source>PubMed Central Open Access</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><creator>Niemiec, Pawel ; Szyluk, Karol ; Balcerzyk, Anna ; Kalita, Marcin ; Jarosz, Alicja ; Iwanicka, Joanna ; Iwanicki, Tomasz ; Nowak, Tomasz ; Negru, Marius ; Francuz, Tomasz ; Garczorz, Wojciech ; Grzeszczak, Wladyslaw ; Gorczynska-Kosiorz, Sylwia ; Kania, Wojciech ; Zak, Iwona</creator><creatorcontrib>Niemiec, Pawel ; Szyluk, Karol ; Balcerzyk, Anna ; Kalita, Marcin ; Jarosz, Alicja ; Iwanicka, Joanna ; Iwanicki, Tomasz ; Nowak, Tomasz ; Negru, Marius ; Francuz, Tomasz ; Garczorz, Wojciech ; Grzeszczak, Wladyslaw ; Gorczynska-Kosiorz, Sylwia ; Kania, Wojciech ; Zak, Iwona</creatorcontrib><description>Background There is variability in individual response to platelet-rich plasma (PRP) therapy in tennis elbow treatment. Genetic variation, especially within genes encoding growth factors may influence the observed inter-individual differences. The purpose of this study was to identify polymorphic variants of the platelet-derived growth factor beta polypeptide gene (PDGFB) that determine an improved individual response to PRP therapy in tennis elbow patients. Methods This prospective cohort study was designed in accordance with STROBE and MIBO guidelines. A cohort of 107 patients (132 elbows, 25 bilateral) was studied, including 65 females (77 elbows) and 42 males (55 elbows), aged 24-64 years (median 46.00 +/- 5.50), with lateral elbow tendinopathy treated with autologous PRP injection. The effectiveness of PRP therapy was recorded in all subjects at 2, 4, 8, 12, 24 and 52 weeks after PRP injection using the Visual Analog Scale (VAS), quick version of Disabilities of the Arm, Shoulder and Hand score (QDASH) and Patient-Rated Tennis Elbow Evaluation (PRTEE). In order to determine the PDGFB variants with the best response to PRP therapy, patient reported outcome measures were compared between individual genotypes within studied polymorphic variants (rs2285099, rs2285097, rs2247128, rs5757572, rs1800817 and rs7289325). The influence of single nucleotide polymorphisms on blood and PRP parameters, including the concentration of PDGF-AB and PDGF-BB proteins was also analyzed. Results Our analysis identified genetic variants of the PDGFB gene that lead to a better response to PRP therapy. The TT (rs2285099) and CC (rs2285097) homozygotes had higher concentration of platelets in whole blood than carriers of other genotypes (p = 0.018) and showed significantly (p < 0.05) lower values of VAS (weeks 2-12), QDASH and PRTEE (weeks 2-24). The rs2285099 and rs2285097 variants formed strong haplotype block (r(2) = 98, D'=100). The AA homozygotes (rs2247128) had significantly lower values of VAS (weeks 4-52), QDASH and PRTEE (weeks 8, 12). Conclusions PDGFB gene's polymorphisms increase the effectiveness of PRP therapy in tennis elbow treatment. Genotyping two polymorphisms of the PDGFB gene, namely rs2285099 (or rs2285097) and rs2247128 may be a helpful diagnostic tool while assessing patients for PRP therapy and modifying the therapy to improve its effectiveness.</description><identifier>ISSN: 1471-2474</identifier><identifier>EISSN: 1471-2474</identifier><identifier>DOI: 10.1186/s12891-021-04593-y</identifier><identifier>PMID: 34407802</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Adult ; Arm ; Blood platelets ; Care and treatment ; Cohort analysis ; Elbow ; Female ; Genes ; Genes, sis ; Genetic analysis ; Genetic aspects ; Genetic diversity ; Genotyping ; Growth factors ; Haplotypes ; Homozygotes ; Humans ; Injection ; Life Sciences & Biomedicine ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Orthopedics ; Pain ; Patients ; PDGFB ; Platelet-derived growth factor ; Platelet-derived growth factor BB ; Platelet-Rich Plasma ; Platelet-rich plasma therapy ; Prospective Studies ; Proteins ; Repetitive motion disorders ; Rheumatology ; Science & Technology ; Single nucleotide polymorphisms ; single nucleotide polymorphisms, gene ; Single-nucleotide polymorphism ; Software ; Tendinopathy ; Tennis elbow ; Tennis Elbow - diagnosis ; Tennis Elbow - genetics ; Tennis Elbow - therapy</subject><ispartof>BMC musculoskeletal disorders, 2021-08, Vol.22 (1), p.710-710, Article 710</ispartof><rights>2021. The Author(s).</rights><rights>COPYRIGHT 2021 BioMed Central Ltd.</rights><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>9</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000686662100006</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c563t-de9534f2a2519d92e2d572900a70a6f29e6ba3d676cef453abb0513595ca8eb73</citedby><cites>FETCH-LOGICAL-c563t-de9534f2a2519d92e2d572900a70a6f29e6ba3d676cef453abb0513595ca8eb73</cites><orcidid>0000-0002-0633-949X ; 0000-0002-0853-9014 ; 0000-0001-5737-3674 ; 0000-0003-0044-3162 ; 0000-0002-8159-6437 ; 0000-0002-3609-9554</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375168/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375168/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,27931,27932,39265,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34407802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niemiec, Pawel</creatorcontrib><creatorcontrib>Szyluk, Karol</creatorcontrib><creatorcontrib>Balcerzyk, Anna</creatorcontrib><creatorcontrib>Kalita, Marcin</creatorcontrib><creatorcontrib>Jarosz, Alicja</creatorcontrib><creatorcontrib>Iwanicka, Joanna</creatorcontrib><creatorcontrib>Iwanicki, Tomasz</creatorcontrib><creatorcontrib>Nowak, Tomasz</creatorcontrib><creatorcontrib>Negru, Marius</creatorcontrib><creatorcontrib>Francuz, Tomasz</creatorcontrib><creatorcontrib>Garczorz, Wojciech</creatorcontrib><creatorcontrib>Grzeszczak, Wladyslaw</creatorcontrib><creatorcontrib>Gorczynska-Kosiorz, Sylwia</creatorcontrib><creatorcontrib>Kania, Wojciech</creatorcontrib><creatorcontrib>Zak, Iwona</creatorcontrib><title>Why PRP works only on certain patients with tennis elbow? Is PDGFB gene a key for PRP therapy effectiveness? A prospective cohort study</title><title>BMC musculoskeletal disorders</title><addtitle>BMC MUSCULOSKEL DIS</addtitle><addtitle>BMC Musculoskelet Disord</addtitle><description>Background There is variability in individual response to platelet-rich plasma (PRP) therapy in tennis elbow treatment. Genetic variation, especially within genes encoding growth factors may influence the observed inter-individual differences. The purpose of this study was to identify polymorphic variants of the platelet-derived growth factor beta polypeptide gene (PDGFB) that determine an improved individual response to PRP therapy in tennis elbow patients. Methods This prospective cohort study was designed in accordance with STROBE and MIBO guidelines. A cohort of 107 patients (132 elbows, 25 bilateral) was studied, including 65 females (77 elbows) and 42 males (55 elbows), aged 24-64 years (median 46.00 +/- 5.50), with lateral elbow tendinopathy treated with autologous PRP injection. The effectiveness of PRP therapy was recorded in all subjects at 2, 4, 8, 12, 24 and 52 weeks after PRP injection using the Visual Analog Scale (VAS), quick version of Disabilities of the Arm, Shoulder and Hand score (QDASH) and Patient-Rated Tennis Elbow Evaluation (PRTEE). In order to determine the PDGFB variants with the best response to PRP therapy, patient reported outcome measures were compared between individual genotypes within studied polymorphic variants (rs2285099, rs2285097, rs2247128, rs5757572, rs1800817 and rs7289325). The influence of single nucleotide polymorphisms on blood and PRP parameters, including the concentration of PDGF-AB and PDGF-BB proteins was also analyzed. Results Our analysis identified genetic variants of the PDGFB gene that lead to a better response to PRP therapy. The TT (rs2285099) and CC (rs2285097) homozygotes had higher concentration of platelets in whole blood than carriers of other genotypes (p = 0.018) and showed significantly (p < 0.05) lower values of VAS (weeks 2-12), QDASH and PRTEE (weeks 2-24). The rs2285099 and rs2285097 variants formed strong haplotype block (r(2) = 98, D'=100). The AA homozygotes (rs2247128) had significantly lower values of VAS (weeks 4-52), QDASH and PRTEE (weeks 8, 12). Conclusions PDGFB gene's polymorphisms increase the effectiveness of PRP therapy in tennis elbow treatment. Genotyping two polymorphisms of the PDGFB gene, namely rs2285099 (or rs2285097) and rs2247128 may be a helpful diagnostic tool while assessing patients for PRP therapy and modifying the therapy to improve its effectiveness.</description><subject>Adult</subject><subject>Arm</subject><subject>Blood platelets</subject><subject>Care and treatment</subject><subject>Cohort analysis</subject><subject>Elbow</subject><subject>Female</subject><subject>Genes</subject><subject>Genes, sis</subject><subject>Genetic analysis</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genotyping</subject><subject>Growth factors</subject><subject>Haplotypes</subject><subject>Homozygotes</subject><subject>Humans</subject><subject>Injection</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Pain</subject><subject>Patients</subject><subject>PDGFB</subject><subject>Platelet-derived growth factor</subject><subject>Platelet-derived growth factor BB</subject><subject>Platelet-Rich Plasma</subject><subject>Platelet-rich plasma therapy</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Repetitive motion disorders</subject><subject>Rheumatology</subject><subject>Science & Technology</subject><subject>Single nucleotide polymorphisms</subject><subject>single nucleotide polymorphisms, gene</subject><subject>Single-nucleotide polymorphism</subject><subject>Software</subject><subject>Tendinopathy</subject><subject>Tennis elbow</subject><subject>Tennis Elbow - diagnosis</subject><subject>Tennis Elbow - genetics</subject><subject>Tennis Elbow - therapy</subject><issn>1471-2474</issn><issn>1471-2474</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbK3-AS8k4I0gW_OdmRvLutpaKFhE8TJkMmd2084ma5LtMr_Av212t5ZWvJCQD06e8x5y8lbVS4KPCanlu0Ro3ZAJpmVy0bDJ-Kg6JFyRCeWKP753PqiepXSFMVE1a55WB4xzrGpMD6tfPxYjuvx6iTYhXicU_DCWBVmI2TiPViY78DmhjcsLlMF7lxAMbdicoPOELj-enX5Ac_CADLqGEfUh7tTyAqJZjQj6Hmx2N4VI6QRN0SqGtNqHkA2LEDNKed2Nz6snvRkSvLjdj6rvp5--zT5PLr6cnc-mFxMrJMuTDhrBeE8NFaTpGgq0E4o2GBuFjexpA7I1rJNKWui5YKZtsSBMNMKaGlrFjqrzvW4XzJVeRbc0cdTBOL0LhDjXJmZnB9B111IrcSMpldxyWUvJVE87xpQSreyK1vu91mrdLqGzpVHRDA9EH954t9DzcKNrpgSRdRF4cysQw881pKyXLlkYBuMhrJOmQtKaUUFFQV__hV6FdfSlVTuqfD_h96i5KQ9wvg-lrt2K6qlUgnLG2bbs8T-oMjpYOhs89K7EHyTQfYItv5ci9HdvJFhvraj3VtTFinpnRT2WpFf3u3OX8sd7BXi7BzbQhj7ZYjQLdxjGeNtxSQneHgtd_z89c7kYN_hZWPvMfgPwm_kf</recordid><startdate>20210818</startdate><enddate>20210818</enddate><creator>Niemiec, Pawel</creator><creator>Szyluk, Karol</creator><creator>Balcerzyk, Anna</creator><creator>Kalita, Marcin</creator><creator>Jarosz, Alicja</creator><creator>Iwanicka, Joanna</creator><creator>Iwanicki, Tomasz</creator><creator>Nowak, Tomasz</creator><creator>Negru, Marius</creator><creator>Francuz, Tomasz</creator><creator>Garczorz, Wojciech</creator><creator>Grzeszczak, Wladyslaw</creator><creator>Gorczynska-Kosiorz, Sylwia</creator><creator>Kania, Wojciech</creator><creator>Zak, Iwona</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0633-949X</orcidid><orcidid>https://orcid.org/0000-0002-0853-9014</orcidid><orcidid>https://orcid.org/0000-0001-5737-3674</orcidid><orcidid>https://orcid.org/0000-0003-0044-3162</orcidid><orcidid>https://orcid.org/0000-0002-8159-6437</orcidid><orcidid>https://orcid.org/0000-0002-3609-9554</orcidid></search><sort><creationdate>20210818</creationdate><title>Why PRP works only on certain patients with tennis elbow? Is PDGFB gene a key for PRP therapy effectiveness? A prospective cohort study</title><author>Niemiec, Pawel ; Szyluk, Karol ; Balcerzyk, Anna ; Kalita, Marcin ; Jarosz, Alicja ; Iwanicka, Joanna ; Iwanicki, Tomasz ; Nowak, Tomasz ; Negru, Marius ; Francuz, Tomasz ; Garczorz, Wojciech ; Grzeszczak, Wladyslaw ; Gorczynska-Kosiorz, Sylwia ; Kania, Wojciech ; Zak, Iwona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-de9534f2a2519d92e2d572900a70a6f29e6ba3d676cef453abb0513595ca8eb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Arm</topic><topic>Blood platelets</topic><topic>Care and treatment</topic><topic>Cohort analysis</topic><topic>Elbow</topic><topic>Female</topic><topic>Genes</topic><topic>Genes, sis</topic><topic>Genetic analysis</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genotyping</topic><topic>Growth factors</topic><topic>Haplotypes</topic><topic>Homozygotes</topic><topic>Humans</topic><topic>Injection</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Pain</topic><topic>Patients</topic><topic>PDGFB</topic><topic>Platelet-derived growth factor</topic><topic>Platelet-derived growth factor BB</topic><topic>Platelet-Rich Plasma</topic><topic>Platelet-rich plasma therapy</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Repetitive motion disorders</topic><topic>Rheumatology</topic><topic>Science & Technology</topic><topic>Single nucleotide polymorphisms</topic><topic>single nucleotide polymorphisms, gene</topic><topic>Single-nucleotide polymorphism</topic><topic>Software</topic><topic>Tendinopathy</topic><topic>Tennis elbow</topic><topic>Tennis Elbow - diagnosis</topic><topic>Tennis Elbow - genetics</topic><topic>Tennis Elbow - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niemiec, Pawel</creatorcontrib><creatorcontrib>Szyluk, Karol</creatorcontrib><creatorcontrib>Balcerzyk, Anna</creatorcontrib><creatorcontrib>Kalita, Marcin</creatorcontrib><creatorcontrib>Jarosz, Alicja</creatorcontrib><creatorcontrib>Iwanicka, Joanna</creatorcontrib><creatorcontrib>Iwanicki, Tomasz</creatorcontrib><creatorcontrib>Nowak, Tomasz</creatorcontrib><creatorcontrib>Negru, Marius</creatorcontrib><creatorcontrib>Francuz, Tomasz</creatorcontrib><creatorcontrib>Garczorz, Wojciech</creatorcontrib><creatorcontrib>Grzeszczak, Wladyslaw</creatorcontrib><creatorcontrib>Gorczynska-Kosiorz, Sylwia</creatorcontrib><creatorcontrib>Kania, Wojciech</creatorcontrib><creatorcontrib>Zak, Iwona</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC musculoskeletal disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niemiec, Pawel</au><au>Szyluk, Karol</au><au>Balcerzyk, Anna</au><au>Kalita, Marcin</au><au>Jarosz, Alicja</au><au>Iwanicka, Joanna</au><au>Iwanicki, Tomasz</au><au>Nowak, Tomasz</au><au>Negru, Marius</au><au>Francuz, Tomasz</au><au>Garczorz, Wojciech</au><au>Grzeszczak, Wladyslaw</au><au>Gorczynska-Kosiorz, Sylwia</au><au>Kania, Wojciech</au><au>Zak, Iwona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Why PRP works only on certain patients with tennis elbow? Is PDGFB gene a key for PRP therapy effectiveness? A prospective cohort study</atitle><jtitle>BMC musculoskeletal disorders</jtitle><stitle>BMC MUSCULOSKEL DIS</stitle><addtitle>BMC Musculoskelet Disord</addtitle><date>2021-08-18</date><risdate>2021</risdate><volume>22</volume><issue>1</issue><spage>710</spage><epage>710</epage><pages>710-710</pages><artnum>710</artnum><issn>1471-2474</issn><eissn>1471-2474</eissn><abstract>Background There is variability in individual response to platelet-rich plasma (PRP) therapy in tennis elbow treatment. Genetic variation, especially within genes encoding growth factors may influence the observed inter-individual differences. The purpose of this study was to identify polymorphic variants of the platelet-derived growth factor beta polypeptide gene (PDGFB) that determine an improved individual response to PRP therapy in tennis elbow patients. Methods This prospective cohort study was designed in accordance with STROBE and MIBO guidelines. A cohort of 107 patients (132 elbows, 25 bilateral) was studied, including 65 females (77 elbows) and 42 males (55 elbows), aged 24-64 years (median 46.00 +/- 5.50), with lateral elbow tendinopathy treated with autologous PRP injection. The effectiveness of PRP therapy was recorded in all subjects at 2, 4, 8, 12, 24 and 52 weeks after PRP injection using the Visual Analog Scale (VAS), quick version of Disabilities of the Arm, Shoulder and Hand score (QDASH) and Patient-Rated Tennis Elbow Evaluation (PRTEE). In order to determine the PDGFB variants with the best response to PRP therapy, patient reported outcome measures were compared between individual genotypes within studied polymorphic variants (rs2285099, rs2285097, rs2247128, rs5757572, rs1800817 and rs7289325). The influence of single nucleotide polymorphisms on blood and PRP parameters, including the concentration of PDGF-AB and PDGF-BB proteins was also analyzed. Results Our analysis identified genetic variants of the PDGFB gene that lead to a better response to PRP therapy. The TT (rs2285099) and CC (rs2285097) homozygotes had higher concentration of platelets in whole blood than carriers of other genotypes (p = 0.018) and showed significantly (p < 0.05) lower values of VAS (weeks 2-12), QDASH and PRTEE (weeks 2-24). The rs2285099 and rs2285097 variants formed strong haplotype block (r(2) = 98, D'=100). The AA homozygotes (rs2247128) had significantly lower values of VAS (weeks 4-52), QDASH and PRTEE (weeks 8, 12). Conclusions PDGFB gene's polymorphisms increase the effectiveness of PRP therapy in tennis elbow treatment. Genotyping two polymorphisms of the PDGFB gene, namely rs2285099 (or rs2285097) and rs2247128 may be a helpful diagnostic tool while assessing patients for PRP therapy and modifying the therapy to improve its effectiveness.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>34407802</pmid><doi>10.1186/s12891-021-04593-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0633-949X</orcidid><orcidid>https://orcid.org/0000-0002-0853-9014</orcidid><orcidid>https://orcid.org/0000-0001-5737-3674</orcidid><orcidid>https://orcid.org/0000-0003-0044-3162</orcidid><orcidid>https://orcid.org/0000-0002-8159-6437</orcidid><orcidid>https://orcid.org/0000-0002-3609-9554</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-2474 |
| ispartof | BMC musculoskeletal disorders, 2021-08, Vol.22 (1), p.710-710, Article 710 |
| issn | 1471-2474 1471-2474 |
| language | eng |
| recordid | cdi_webofscience_primary_000686662100006CitationCount |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; PubMed Central Open Access; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Adult Arm Blood platelets Care and treatment Cohort analysis Elbow Female Genes Genes, sis Genetic analysis Genetic aspects Genetic diversity Genotyping Growth factors Haplotypes Homozygotes Humans Injection Life Sciences & Biomedicine Male Medical research Medicine, Experimental Middle Aged Orthopedics Pain Patients PDGFB Platelet-derived growth factor Platelet-derived growth factor BB Platelet-Rich Plasma Platelet-rich plasma therapy Prospective Studies Proteins Repetitive motion disorders Rheumatology Science & Technology Single nucleotide polymorphisms single nucleotide polymorphisms, gene Single-nucleotide polymorphism Software Tendinopathy Tennis elbow Tennis Elbow - diagnosis Tennis Elbow - genetics Tennis Elbow - therapy |
| title | Why PRP works only on certain patients with tennis elbow? Is PDGFB gene a key for PRP therapy effectiveness? A prospective cohort study |
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