Harmful R-loops are prevented via different cell cycle-specific mechanisms

Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by genome-wide analysis of conditional yeast mutants that the THO transcription complex, prevents R-loop formation in G1 and S-phase, whereas the Sen1 DNA-RNA helicase prevents them only...

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Veröffentlicht in:	Nature communications 2021-07, Vol.12 (1), p.4451-4451, Article 4451
Hauptverfasser:	San Martin-Alonso, Marta, Soler-Oliva, María E., García-Rubio, María, García-Muse, Tatiana, Aguilera, Andrés
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/63 38 38/15 38/22 38/35 38/44 45 631/208/211 631/337/1644 Cell cycle Cell Cycle - genetics Cell Cycle - physiology Damage accumulation Deoxyribonucleic acid DNA DNA biosynthesis DNA Damage DNA helicase DNA Helicases - genetics DNA Helicases - metabolism DNA, Fungal - chemistry DNA, Fungal - genetics DNA, Fungal - metabolism Genes, Fungal Genomes Genomic Instability Homeostasis Humanities and Social Sciences Models, Biological multidisciplinary Mutants Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism R-Loop Structures - genetics R-Loop Structures - physiology R-loops Replication Resolvase RNA helicase RNA Helicases - genetics RNA Helicases - metabolism RNA, Fungal - chemistry RNA, Fungal - genetics RNA, Fungal - metabolism Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary) Transcription Transcription Factors - genetics Transcription Factors - metabolism Yeasts
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