Linking periodontitis and adverse pregnancy outcomes through CD14+ CD16+ monocytes
One of the prevalent medical issues that deserve global attention is adverse pregnancy outcomes and preterm low birth weight deliveries which have a significant impact on neonatal health. Periodontitis has been implicated as a significant risk factor for adverse effects in pregnancy. Elevated levels...
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| Veröffentlicht in: | Medical hypotheses 2021-08, Vol.153, p.110637-110637, Article 110637 |
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| container_title | Medical hypotheses |
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| creator | Jagannathan, Raghunathan Balaji, Thodur Madapusi Varadarajan, Saranya Bhuvaneswari, B. Venkatakrishnan, C.J. Lakshmi Priya, S. Rajendran, Swaminathan Sayed, Mohammed E. Mugri, Maryam H. Patil, Shankargouda |
| description | One of the prevalent medical issues that deserve global attention is adverse pregnancy outcomes and preterm low birth weight deliveries which have a significant impact on neonatal health. Periodontitis has been implicated as a significant risk factor for adverse effects in pregnancy. Elevated levels of periodontal pathogenic bacteria and proinflammatory cytokines which are pathognomonic features of periodontitis are believed to cause placental infection and premature rupture of the amniotic membrane consequently leading to preterm delivery. The role of CD14+CD16+ monocytes as a causal link between periodontitis and adverse pregnancy outcomes has not been researched so far, although an elevation of these cells has been independently demonstrated in both conditions. With the available background information, this hypothesis attempts to derive a mechanistic link between periodontitis and adverse pregnancy outcomes through the participation of CD14+CD16+ monocytes. |
| doi_str_mv | 10.1016/j.mehy.2021.110637 |
| format | Article |
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Periodontitis has been implicated as a significant risk factor for adverse effects in pregnancy. Elevated levels of periodontal pathogenic bacteria and proinflammatory cytokines which are pathognomonic features of periodontitis are believed to cause placental infection and premature rupture of the amniotic membrane consequently leading to preterm delivery. The role of CD14+CD16+ monocytes as a causal link between periodontitis and adverse pregnancy outcomes has not been researched so far, although an elevation of these cells has been independently demonstrated in both conditions. With the available background information, this hypothesis attempts to derive a mechanistic link between periodontitis and adverse pregnancy outcomes through the participation of CD14+CD16+ monocytes.</description><subject>Adverse effects</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine, Research & Experimental</subject><subject>Monocytes</subject><subject>Periodontitis</subject><subject>Pregnancy</subject><subject>Research & Experimental Medicine</subject><subject>Science & Technology</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkM-LEzEUgIMobnf1H_A0R6FMze9JwIt01RUKgug5ZJLXNrWT1CSz0v_eGWbxKF7eu3zf4_Eh9IbgDcFEvjttBjheNxRTsiEES9Y9QysiGG1p13XP0QozLFutuu4G3ZZywhhrztRLdMM4UZIzvULfdiH-DPHQXCCH5FOsoYbS2Ogb6x8hF2guGQ7RRndt0lhdGqA09ZjTeDg223vC1_OU62ZIMblrhfIKvdjbc4HXT_sO_fj08fv2od19_fxl-2HXOqp4bZm3guOOcRC6l75XSnd0j7nglGtMe6y0B2E5wcIywZ3UWgrfa4w9aK2B3aG3y91LTr9GKNUMoTg4n22ENBZDBZdaYS30hNIFdTmVkmFvLjkMNl8NwWZuaU5mbmnmlmZpOUlqkX5Dn_bFBYgO_opTTKkkpVjiues2VFtDits0xjqp6_9XJ_r9QsNU6zFANk-GDxlcNT6Ff_35B3iZmkM</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Jagannathan, Raghunathan</creator><creator>Balaji, Thodur Madapusi</creator><creator>Varadarajan, Saranya</creator><creator>Bhuvaneswari, B.</creator><creator>Venkatakrishnan, C.J.</creator><creator>Lakshmi Priya, S.</creator><creator>Rajendran, Swaminathan</creator><creator>Sayed, Mohammed E.</creator><creator>Mugri, Maryam H.</creator><creator>Patil, Shankargouda</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202108</creationdate><title>Linking periodontitis and adverse pregnancy outcomes through CD14+ CD16+ monocytes</title><author>Jagannathan, Raghunathan ; Balaji, Thodur Madapusi ; Varadarajan, Saranya ; Bhuvaneswari, B. ; Venkatakrishnan, C.J. ; Lakshmi Priya, S. ; Rajendran, Swaminathan ; Sayed, Mohammed E. ; Mugri, Maryam H. ; Patil, Shankargouda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-3da540734e59b6db88972f045424902b089de5a4105a354c69965db900de999e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adverse effects</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine, Research & Experimental</topic><topic>Monocytes</topic><topic>Periodontitis</topic><topic>Pregnancy</topic><topic>Research & Experimental Medicine</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jagannathan, Raghunathan</creatorcontrib><creatorcontrib>Balaji, Thodur Madapusi</creatorcontrib><creatorcontrib>Varadarajan, Saranya</creatorcontrib><creatorcontrib>Bhuvaneswari, B.</creatorcontrib><creatorcontrib>Venkatakrishnan, C.J.</creatorcontrib><creatorcontrib>Lakshmi Priya, S.</creatorcontrib><creatorcontrib>Rajendran, Swaminathan</creatorcontrib><creatorcontrib>Sayed, Mohammed E.</creatorcontrib><creatorcontrib>Mugri, Maryam H.</creatorcontrib><creatorcontrib>Patil, Shankargouda</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jagannathan, Raghunathan</au><au>Balaji, Thodur Madapusi</au><au>Varadarajan, Saranya</au><au>Bhuvaneswari, B.</au><au>Venkatakrishnan, C.J.</au><au>Lakshmi Priya, S.</au><au>Rajendran, Swaminathan</au><au>Sayed, Mohammed E.</au><au>Mugri, Maryam H.</au><au>Patil, Shankargouda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linking periodontitis and adverse pregnancy outcomes through CD14+ CD16+ monocytes</atitle><jtitle>Medical hypotheses</jtitle><stitle>MED HYPOTHESES</stitle><date>2021-08</date><risdate>2021</risdate><volume>153</volume><spage>110637</spage><epage>110637</epage><pages>110637-110637</pages><artnum>110637</artnum><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>One of the prevalent medical issues that deserve global attention is adverse pregnancy outcomes and preterm low birth weight deliveries which have a significant impact on neonatal health. 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| source | Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Access via ScienceDirect (Elsevier) |
| subjects | Adverse effects Life Sciences & Biomedicine Medicine, Research & Experimental Monocytes Periodontitis Pregnancy Research & Experimental Medicine Science & Technology |
| title | Linking periodontitis and adverse pregnancy outcomes through CD14+ CD16+ monocytes |
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