TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain

Microglial activation-induced neuroinflammation is critical in the pathogenesis of neurodegenerative diseases. Activated microglia are regulated mainly by innate pattern recognition receptors (PRRs) on their surface, of which macrophage receptor with collagenous structure (Marco) is a well-character...

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Veröffentlicht in:	Molecular neurobiology 2021-11, Vol.58 (11), p.5743-5755
Hauptverfasser:	Wang, Lu, Yang, Han-Yu, Zang, Cai-Xia, Shang, Jun-Mei, Liu, Hui, Zhang, Zi-Hong, Yuan, Fang-Yu, Ju, Cheng, Li, Fang-Yuan, Bao, Xiu-Qi, Zhang, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - pharmacology Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Line Collagen Gene Knockdown Techniques HEK293 Cells Humans Inflammation Life Sciences & Biomedicine Macrophages Male MARCO protein Mice Mice, Inbred C57BL Microglia Neurobiology Neurodegenerative diseases Neuroinflammatory Diseases - metabolism Neurology Neurosciences Neurosciences & Neurology Nitric Oxide - metabolism Pathogenesis Pattern recognition receptors Polysaccharides - pharmacology Protein Binding Protein Domains Protein Interaction Mapping Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - chemistry Receptors, Immunologic - metabolism Recombinant Proteins - metabolism RNA Interference Scavenger receptors Science & Technology Substantia nigra TLR2 protein Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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