Levels of circulating GRP78 and CHOP in endoplasmic reticulum stress pathways in Chinese type 2 diabetic kidney disease patients

The current study aimed to investigate circulating glucose-regulated protein 78 (GRP78) as well as CCAAT/enhancer-binding protein homologous protein (CHOP) concentrations in Chinese type 2 diabetes mellitus (T2DM) patients, especially those with microalbuminuria. We recruited 67 patients with T2DM a...

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Veröffentlicht in:	Medicine (Baltimore) 2021-08, Vol.100 (33), p.e26879-e26879
Hauptverfasser:	Ma, Ning, Xu, Ning, Yin, Dong, Zheng, Ping, Liu, Weiwei, Wang, Guofeng, Hui, Yuan, Han, Guanjun, Yang, Chuanhui, Cheng, Xingbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Asian People Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetic Nephropathies - blood Endoplasmic Reticulum Chaperone BiP Endoplasmic Reticulum Stress Female Heat-Shock Proteins - blood Humans Male Middle Aged Observational Study Transcription Factor CHOP - blood
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Zusammenfassung:	The current study aimed to investigate circulating glucose-regulated protein 78 (GRP78) as well as CCAAT/enhancer-binding protein homologous protein (CHOP) concentrations in Chinese type 2 diabetes mellitus (T2DM) patients, especially those with microalbuminuria. We recruited 67 patients with T2DM and 63 control subjects. We determined circulating GRP78 and CHOP concentrations by ELISA, collected anthropometric data, and measured biochemical parameters in a clinical laboratory. Compared with control groups, patients with T2DM showed decreased circulating levels of GRP78 (0.21 [0.16-0.24] vs 0.16 [0.16-0.19] ng/mL, P
ISSN:	0025-7974 1536-5964
DOI:	10.1097/MD.0000000000026879