Negative allosteric modulation of metabotropic glutamate receptor 5 attenuates alcohol self-administration in baboons

Many of the behavioral symptoms that define alcohol use disorder (AUD) are thought to be mediated by amplified glutamatergic activity. As a result, previous preclinical studies have investigated glutamate receptor inhibition as a potential pharmacotherapy for AUD, particularly the metabotropic gluta...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2021-09, Vol.208, p.173227-173227, Article 173227
Hauptverfasser:	Salling, Michael C., Grassetti, Alexander, Ferrera, Vincent P., Martinez, Diana, Foltin, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol self-administration mGlu5 Non-human primate
Online-Zugang:	Volltext
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