Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series
New thiosemicarbazones were synthesized in excellent yield reaction of indole derivatives with thiosemicarbazides. These thiosemicarbazones were reacted with ethyl bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group. Analytical IR and NM...
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| Veröffentlicht in: | Monatshefte für Chemie 2021-08, Vol.152 (8), p.977-986 |
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| creator | Benmohammed, Abdelmadjid Rekiba, Nawel Sehanine, Yassine Louail, Ahmed Amine Khoumeri, Omar Kadiri, Mokhtaria Djafri, Ayada Terme, Thierry Vanelle, Patrice |
| description | New thiosemicarbazones were synthesized in excellent yield reaction of indole derivatives with thiosemicarbazides. These thiosemicarbazones were reacted with ethyl bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group. Analytical IR and NMR spectra and elemental analysis were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. Antibacterial screening data showed that two compounds demonstrated activity against
Staphylococcus aureus
,
Escherichia coli
, and
Pseudomonas aeruginosa
. These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency
.
Graphic abstract |
| doi_str_mv | 10.1007/s00706-021-02823-6 |
| format | Article |
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Staphylococcus aureus
,
Escherichia coli
, and
Pseudomonas aeruginosa
. These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency
.
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Staphylococcus aureus
,
Escherichia coli
, and
Pseudomonas aeruginosa
. These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency
.
Graphic abstract</description><subject>Analytical Chemistry</subject><subject>Antimicrobial agents</subject><subject>Chemical analysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry, Multidisciplinary</subject><subject>Chemistry/Food Science</subject><subject>E coli</subject><subject>Inorganic Chemistry</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Physical Chemistry</subject><subject>Physical Sciences</subject><subject>Pseudomonas aeruginosa</subject><subject>Science & Technology</subject><subject>Theoretical and Computational Chemistry</subject><issn>0026-9247</issn><issn>1434-4475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkE1LxDAQhoMouK7-AU8Fj1LNV9P2KItfIHhQzyHNh0a6yZpkFf31jlvRmwiZTGZ4nyTzInRI8AnBuD3NsGFRY0ogOspqsYVmhDNec94222iGMRV1T3m7i_ZyfsZQc8xmyN69h_Jks8-VCgai-KXXKQ5ejZXSxb_64m2uoquCfavKk4_ZgkKlQX3EYCcM2lCN3viw6fkAy8TRVtkmwPfRjlNjtgffeY4eLs7vF1f1ze3l9eLsptaM9KXuGq5Ep10vnBuEsazpTWuYEgM12ugWRuWaMNO2whku8OAYYZRr3TtKXYfZHB1N965SfFnbXORzXKcAT0raCNw1tAdz5ohOKpgz52SdXCW_VOldEiy_7JSTnRLslBs7pQCom6A3O0SXtbdB2x8Q_BQdo4xxOGGy8EUVH8MirkMB9Pj_KKjZpM6gCI82_c7wx_c-AZfRmtU</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Benmohammed, Abdelmadjid</creator><creator>Rekiba, Nawel</creator><creator>Sehanine, Yassine</creator><creator>Louail, Ahmed Amine</creator><creator>Khoumeri, Omar</creator><creator>Kadiri, Mokhtaria</creator><creator>Djafri, Ayada</creator><creator>Terme, Thierry</creator><creator>Vanelle, Patrice</creator><general>Springer Vienna</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>1KM</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-3247-0587</orcidid></search><sort><creationdate>20210801</creationdate><title>Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series</title><author>Benmohammed, Abdelmadjid ; Rekiba, Nawel ; Sehanine, Yassine ; Louail, Ahmed Amine ; Khoumeri, Omar ; Kadiri, Mokhtaria ; Djafri, Ayada ; Terme, Thierry ; Vanelle, Patrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-854a68cf96ffb6de359d7d3a6b2dcdc71004c13d776fd460bf31324cc9f22f803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analytical Chemistry</topic><topic>Antimicrobial agents</topic><topic>Chemical analysis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry, Multidisciplinary</topic><topic>Chemistry/Food Science</topic><topic>E coli</topic><topic>Inorganic Chemistry</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Physical Chemistry</topic><topic>Physical Sciences</topic><topic>Pseudomonas aeruginosa</topic><topic>Science & Technology</topic><topic>Theoretical and Computational Chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benmohammed, Abdelmadjid</creatorcontrib><creatorcontrib>Rekiba, Nawel</creatorcontrib><creatorcontrib>Sehanine, Yassine</creatorcontrib><creatorcontrib>Louail, Ahmed Amine</creatorcontrib><creatorcontrib>Khoumeri, Omar</creatorcontrib><creatorcontrib>Kadiri, Mokhtaria</creatorcontrib><creatorcontrib>Djafri, Ayada</creatorcontrib><creatorcontrib>Terme, Thierry</creatorcontrib><creatorcontrib>Vanelle, Patrice</creatorcontrib><collection>Index Chemicus</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><jtitle>Monatshefte für Chemie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benmohammed, Abdelmadjid</au><au>Rekiba, Nawel</au><au>Sehanine, Yassine</au><au>Louail, Ahmed Amine</au><au>Khoumeri, Omar</au><au>Kadiri, Mokhtaria</au><au>Djafri, Ayada</au><au>Terme, Thierry</au><au>Vanelle, Patrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series</atitle><jtitle>Monatshefte für Chemie</jtitle><stitle>Monatsh Chem</stitle><stitle>MONATSH CHEM</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>152</volume><issue>8</issue><spage>977</spage><epage>986</epage><pages>977-986</pages><issn>0026-9247</issn><eissn>1434-4475</eissn><abstract>New thiosemicarbazones were synthesized in excellent yield reaction of indole derivatives with thiosemicarbazides. These thiosemicarbazones were reacted with ethyl bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group. Analytical IR and NMR spectra and elemental analysis were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. Antibacterial screening data showed that two compounds demonstrated activity against
Staphylococcus aureus
,
Escherichia coli
, and
Pseudomonas aeruginosa
. These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency
.
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| subjects | Analytical Chemistry Antimicrobial agents Chemical analysis Chemistry Chemistry and Materials Science Chemistry, Multidisciplinary Chemistry/Food Science E coli Inorganic Chemistry NMR Nuclear magnetic resonance Organic Chemistry Original Paper Physical Chemistry Physical Sciences Pseudomonas aeruginosa Science & Technology Theoretical and Computational Chemistry |
| title | Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series |
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