Safety and pharmacokinetics of docetaxel in combination with pegvorhyaluronidase alfa in patients with non‐small cell lung cancer

This open‐label, phase Ib study (NCT02346370) assessed the effect of pegvorhyaluronidase alfa (PVHA; PEGPH20) on the plasma pharmacokinetics (PKs) and safety of docetaxel in 15 patients with stage IIIB/IV non‐small cell lung cancer (NSCLC). The docetaxel PK profile from this study was consistent wit...

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Veröffentlicht in:	Clinical and translational science 2021-09, Vol.14 (5), p.1875-1885
Hauptverfasser:	Heineman, Thomas, Baumgart, Megan, Nanavati, Charvi, Gabrail, Nash, Van Wart, Scott A., Mager, Donald E., Maneval, Daniel C., Fathallah, Anas M., Sekulovich, Rose E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Bayesian analysis Cancer therapies Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Chemotherapy Creatinine Cytotoxicity Docetaxel - administration & dosage Docetaxel - adverse effects Docetaxel - pharmacokinetics Dose-Response Relationship, Drug Female Humans Hyaluronic acid Hyaluronoglucosaminidase - administration & dosage Hyaluronoglucosaminidase - adverse effects Hyaluronoglucosaminidase - pharmacokinetics Life Sciences & Biomedicine Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Medical prognosis Medicine, Research & Experimental Metastasis Middle Aged Myalgia Neoplasm Staging Non-small cell lung carcinoma Patients Pharmacokinetics Plasma Prostate cancer Research & Experimental Medicine Safety Science & Technology Skin cancer Small cell lung carcinoma Thromboembolism Tumors
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