Insulin‐like growth factor 1 gene transfer for sporadic Alzheimer's disease: New evidence for trophic factor mediated hippocampal neuronal and synaptic recovery‐based behavior improvement

Sporadic Alzheimer's disease (sAD) is the most prevalent neurodegenerative disorder with no cure. Patients typically suffer from cognitive impairment imprinted by irreversible neocortex and hippocampal degeneration with overt synaptic and neuron dysfunction. Insulin‐like growth factor 1 (IGF1)...

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Veröffentlicht in:	Hippocampus 2021-10, Vol.31 (10), p.1137-1153
Hauptverfasser:	Zappa Villar, María Florencia, López Hanotte, Juliette, Crespo, Rosana, Pardo, Joaquín, Reggiani, Paula Cecilia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - therapy Alzheimer's disease Animal cognition Animal models Animals Basic Medicine cognition Cognitive ability Disease Models, Animal Gene transfer Growth factors hippocampal proteins Hippocampus Hippocampus - metabolism Humans IGF1 Igf1 gene Inflammation Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Life Sciences & Biomedicine Male Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Memory Microglial cells Neocortex Neurodegeneration Neurodegenerative diseases Neurons - metabolism Neuroprotection Neurosciences Neurosciences & Neurology Neurovetenskaper Postsynaptic density proteins Rats Rats, Sprague-Dawley Recovery of function Science & Technology Signal transduction Spatial memory sporadic Alzheimer's disease Streptozocin streptozotocin Synaptic plasticity Tau protein
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