The combination of N-13-ammonia and C-11-methionine in differentiation of residual/recurrent pituitary adenoma from the pituitary gland remnant after trans-sphenoidal Adenomectomy
BackgroundThis study aimed to assess the clinical usefulness of N-13-ammonia and C-11- Methionine (MET) positron emission tomography (PET)/ computed tomography (CT) in the differentiation of residual/recurrent pituitary adenoma (RPA) from the pituitary gland remnant (PGR) after trans-sphenoidal aden...
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| Veröffentlicht in: | BMC cancer 2021-07, Vol.21 (1), Article 837 |
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| creator | Zhang, Fangling He, Qiao Luo, Ganhua Long, Yali Li, Ruocheng Ding, Lei Zhang, Xiangsong |
| description | BackgroundThis study aimed to assess the clinical usefulness of N-13-ammonia and C-11- Methionine (MET) positron emission tomography (PET)/ computed tomography (CT) in the differentiation of residual/recurrent pituitary adenoma (RPA) from the pituitary gland remnant (PGR) after trans-sphenoidal adenomectomy.MethodsBetween June 2012 and December 2019, a total of 19 patients with a history of trans-sphenoidal adenomectomy before PET/CT scans and histological confirmation of RPA after additional surgery in our hospital were enrolled in this study. Images were interpreted by visual evaluation and semi-quantitative analysis. In semi-quantitative analysis, the maximum standard uptake value (SUVmax) of the target and gray matter was measured and the target uptake/gray matter uptake (T/G) ratio was calculated.ResultsThe T/G ratios of N-13-ammonia were significantly higher in PGR than RPA (1.580.69 vs 0.63 +/- 1.37, P |
| doi_str_mv | 10.1186/s12885-021-08574-1 |
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Images were interpreted by visual evaluation and semi-quantitative analysis. In semi-quantitative analysis, the maximum standard uptake value (SUVmax) of the target and gray matter was measured and the target uptake/gray matter uptake (T/G) ratio was calculated.ResultsThe T/G ratios of N-13-ammonia were significantly higher in PGR than RPA (1.580.69 vs 0.63 +/- 1.37, P<0.001), whereas the T/G ratios of C-11-MET were obviously lower in PGR than RPA (0.78<plus/minus>0.35 vs 2.17 +/- 0.54, P<0.001). Using the canonical discriminant analysis, we calculated the predicted accuracy of RPA (100%), PGR (92.9%), and the overall predicted accuracy (96.43%).Conclusions The combination of N-13-ammonia and C-11-MET PET/CT is valuable in the differentiation of RPA from PGR after trans-sphenoidal adenomectomy.</description><identifier>EISSN: 1471-2407</identifier><identifier>DOI: 10.1186/s12885-021-08574-1</identifier><identifier>PMID: 34284745</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Life Sciences & Biomedicine ; Oncology ; Science & Technology</subject><ispartof>BMC cancer, 2021-07, Vol.21 (1), Article 837</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000677511600004</woscitedreferencesoriginalsourcerecordid><cites>FETCH-webofscience_primary_0006775116000043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,2115,27929,27930,39263</link.rule.ids></links><search><creatorcontrib>Zhang, Fangling</creatorcontrib><creatorcontrib>He, Qiao</creatorcontrib><creatorcontrib>Luo, Ganhua</creatorcontrib><creatorcontrib>Long, Yali</creatorcontrib><creatorcontrib>Li, Ruocheng</creatorcontrib><creatorcontrib>Ding, Lei</creatorcontrib><creatorcontrib>Zhang, Xiangsong</creatorcontrib><title>The combination of N-13-ammonia and C-11-methionine in differentiation of residual/recurrent pituitary adenoma from the pituitary gland remnant after trans-sphenoidal Adenomectomy</title><title>BMC cancer</title><addtitle>BMC CANCER</addtitle><description>BackgroundThis study aimed to assess the clinical usefulness of N-13-ammonia and C-11- Methionine (MET) positron emission tomography (PET)/ computed tomography (CT) in the differentiation of residual/recurrent pituitary adenoma (RPA) from the pituitary gland remnant (PGR) after trans-sphenoidal adenomectomy.MethodsBetween June 2012 and December 2019, a total of 19 patients with a history of trans-sphenoidal adenomectomy before PET/CT scans and histological confirmation of RPA after additional surgery in our hospital were enrolled in this study. Images were interpreted by visual evaluation and semi-quantitative analysis. In semi-quantitative analysis, the maximum standard uptake value (SUVmax) of the target and gray matter was measured and the target uptake/gray matter uptake (T/G) ratio was calculated.ResultsThe T/G ratios of N-13-ammonia were significantly higher in PGR than RPA (1.580.69 vs 0.63 +/- 1.37, P<0.001), whereas the T/G ratios of C-11-MET were obviously lower in PGR than RPA (0.78<plus/minus>0.35 vs 2.17 +/- 0.54, P<0.001). Using the canonical discriminant analysis, we calculated the predicted accuracy of RPA (100%), PGR (92.9%), and the overall predicted accuracy (96.43%).Conclusions The combination of N-13-ammonia and C-11-MET PET/CT is valuable in the differentiation of RPA from PGR after trans-sphenoidal adenomectomy.</description><subject>Life Sciences & Biomedicine</subject><subject>Oncology</subject><subject>Science & Technology</subject><issn>1471-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqVj0FLAzEQhYMgtlb_gKfcJTazm21ylUXx5Ml7me5ObGSTlCSL9Hf5B01F9KqnGXjvm_eGsRuQdwBms87QGNMJ2YCQptNKwBlbgtIgGiX1gl3m_CYlaCPNBVu0qjFKq27JPl72xIfody5gcTHwaPmzgFag9zE45BhG3gsA4ansq8EF4i7w0VlLiUJxP1ii7MYZp3WiYU4njR9cmV3BdOQ4UogeuU3R81Izf6XX6ZSRyAesCNpCiZeEIYt82FfKjTjx-y-ehhL98YqdW5wyXX_PFbt9fHjpn8Q77aLNg6Mw0PaQnK_nt1LKjdYdwKZuUrUrZv7u7mvF0399nENp_xf0CS_hgYk</recordid><startdate>20210720</startdate><enddate>20210720</enddate><creator>Zhang, Fangling</creator><creator>He, Qiao</creator><creator>Luo, Ganhua</creator><creator>Long, Yali</creator><creator>Li, Ruocheng</creator><creator>Ding, Lei</creator><creator>Zhang, Xiangsong</creator><general>Springer Nature</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope></search><sort><creationdate>20210720</creationdate><title>The combination of N-13-ammonia and C-11-methionine in differentiation of residual/recurrent pituitary adenoma from the pituitary gland remnant after trans-sphenoidal Adenomectomy</title><author>Zhang, Fangling ; He, Qiao ; Luo, Ganhua ; Long, Yali ; Li, Ruocheng ; Ding, Lei ; Zhang, Xiangsong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-webofscience_primary_0006775116000043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Life Sciences & Biomedicine</topic><topic>Oncology</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Fangling</creatorcontrib><creatorcontrib>He, Qiao</creatorcontrib><creatorcontrib>Luo, Ganhua</creatorcontrib><creatorcontrib>Long, Yali</creatorcontrib><creatorcontrib>Li, Ruocheng</creatorcontrib><creatorcontrib>Ding, Lei</creatorcontrib><creatorcontrib>Zhang, Xiangsong</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><jtitle>BMC cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Fangling</au><au>He, Qiao</au><au>Luo, Ganhua</au><au>Long, Yali</au><au>Li, Ruocheng</au><au>Ding, Lei</au><au>Zhang, Xiangsong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The combination of N-13-ammonia and C-11-methionine in differentiation of residual/recurrent pituitary adenoma from the pituitary gland remnant after trans-sphenoidal Adenomectomy</atitle><jtitle>BMC cancer</jtitle><stitle>BMC CANCER</stitle><date>2021-07-20</date><risdate>2021</risdate><volume>21</volume><issue>1</issue><artnum>837</artnum><eissn>1471-2407</eissn><abstract>BackgroundThis study aimed to assess the clinical usefulness of N-13-ammonia and C-11- Methionine (MET) positron emission tomography (PET)/ computed tomography (CT) in the differentiation of residual/recurrent pituitary adenoma (RPA) from the pituitary gland remnant (PGR) after trans-sphenoidal adenomectomy.MethodsBetween June 2012 and December 2019, a total of 19 patients with a history of trans-sphenoidal adenomectomy before PET/CT scans and histological confirmation of RPA after additional surgery in our hospital were enrolled in this study. Images were interpreted by visual evaluation and semi-quantitative analysis. In semi-quantitative analysis, the maximum standard uptake value (SUVmax) of the target and gray matter was measured and the target uptake/gray matter uptake (T/G) ratio was calculated.ResultsThe T/G ratios of N-13-ammonia were significantly higher in PGR than RPA (1.580.69 vs 0.63 +/- 1.37, P<0.001), whereas the T/G ratios of C-11-MET were obviously lower in PGR than RPA (0.78<plus/minus>0.35 vs 2.17 +/- 0.54, P<0.001). Using the canonical discriminant analysis, we calculated the predicted accuracy of RPA (100%), PGR (92.9%), and the overall predicted accuracy (96.43%).Conclusions The combination of N-13-ammonia and C-11-MET PET/CT is valuable in the differentiation of RPA from PGR after trans-sphenoidal adenomectomy.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>34284745</pmid><doi>10.1186/s12885-021-08574-1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central |
| subjects | Life Sciences & Biomedicine Oncology Science & Technology |
| title | The combination of N-13-ammonia and C-11-methionine in differentiation of residual/recurrent pituitary adenoma from the pituitary gland remnant after trans-sphenoidal Adenomectomy |
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