Photocuring Hyaluronic Acid/Silk Fibroin Hydrogel Containing Curcumin Loaded CHITOSAN Nanoparticles for the Treatment of MG-63 Cells and ME3T3-E1 Cells
After an osteosarcoma excision, recurrence and bone defects are significant challenges for clinicians. In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel for the osteosa...
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| Veröffentlicht in: | Polymers 2021-07, Vol.13 (14), p.2302, Article 2302 |
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| creator | Yu, Qingwen Meng, Zhiyuan Liu, Yichao Li, Zehao Sun, Xing Zhao, Zheng |
| description | After an osteosarcoma excision, recurrence and bone defects are significant challenges for clinicians. In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel for the osteosarcoma therapy and bone regeneration was developed by photocuring and ethanol treatment. The micro or nanofibers networks were observed in the CCNPs-SF/HAMA hydrogel. The FTIR results demonstrated that alcohol vapor treatment caused an increase in beta-sheets of SF, resulting in the high compression stress and Young's modulus of CCNPs-SF/HAMA hydrogel. According to the water uptake analysis, SF caused a slight decrease in water uptake of CCNPs-SF/HAMA hydrogel while CCNPs could enhance the water uptake of it. The swelling kinetic results showed that both the CCNPs and the SF increased the swelling ratio of CCNPs-SF/HAMA hydrogel. The accumulative release profile of CCNPs-SF/HAMA hydrogel showed that the release of Cur from CCNPs-SF/HAMA hydrogel was accelerated when pH value was decreased from 7.4 to 5.5. Besides, compared with CCNPs, the CCNPs-SF/HAMA hydrogel had a more sustainable drug release, which was beneficial for the long-term treatment of osteosarcoma. In vitro assay results indicated that CCNPs-SF/HAMA hydrogel with equivalent Cur concentration of 150 mu g/mL possessed both the effect of anti-cancer and promoting the proliferation of osteoblasts. These results suggest that CCNPs-SF/HAMA hydrogel with superior physical properties and the bifunctional osteosarcoma therapy and bone repair may be an excellent candidate for local cancer therapy and bone regeneration. |
| doi_str_mv | 10.3390/polym13142302 |
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In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel for the osteosarcoma therapy and bone regeneration was developed by photocuring and ethanol treatment. The micro or nanofibers networks were observed in the CCNPs-SF/HAMA hydrogel. The FTIR results demonstrated that alcohol vapor treatment caused an increase in beta-sheets of SF, resulting in the high compression stress and Young's modulus of CCNPs-SF/HAMA hydrogel. According to the water uptake analysis, SF caused a slight decrease in water uptake of CCNPs-SF/HAMA hydrogel while CCNPs could enhance the water uptake of it. The swelling kinetic results showed that both the CCNPs and the SF increased the swelling ratio of CCNPs-SF/HAMA hydrogel. The accumulative release profile of CCNPs-SF/HAMA hydrogel showed that the release of Cur from CCNPs-SF/HAMA hydrogel was accelerated when pH value was decreased from 7.4 to 5.5. Besides, compared with CCNPs, the CCNPs-SF/HAMA hydrogel had a more sustainable drug release, which was beneficial for the long-term treatment of osteosarcoma. In vitro assay results indicated that CCNPs-SF/HAMA hydrogel with equivalent Cur concentration of 150 mu g/mL possessed both the effect of anti-cancer and promoting the proliferation of osteoblasts. These results suggest that CCNPs-SF/HAMA hydrogel with superior physical properties and the bifunctional osteosarcoma therapy and bone repair may be an excellent candidate for local cancer therapy and bone regeneration.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym13142302</identifier><identifier>PMID: 34301063</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Anticancer properties ; Bioavailability ; Biocompatibility ; Biomedical materials ; Bone cancer ; Cancer therapies ; Chemotherapy ; Chitosan ; Drug delivery systems ; Esterification ; Ethanol ; Extracellular matrix ; Hyaluronic acid ; Hydrogels ; Mechanical properties ; Microscopy ; Modulus of elasticity ; Morphology ; Nanofibers ; Nanoparticles ; Particle size ; Physical properties ; Physical Sciences ; Polymer Science ; Regeneration (physiology) ; Science & Technology ; Silk fibroin ; Swelling ratio ; Therapy</subject><ispartof>Polymers, 2021-07, Vol.13 (14), p.2302, Article 2302</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>38</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000677019500001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c458t-3fb134372cab600aabd361012fccf078e5ebb80e793660aa90416d062a03e12a3</citedby><cites>FETCH-LOGICAL-c458t-3fb134372cab600aabd361012fccf078e5ebb80e793660aa90416d062a03e12a3</cites><orcidid>0000-0002-0574-3095</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309346/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309346/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,39263,53796,53798</link.rule.ids></links><search><creatorcontrib>Yu, Qingwen</creatorcontrib><creatorcontrib>Meng, Zhiyuan</creatorcontrib><creatorcontrib>Liu, Yichao</creatorcontrib><creatorcontrib>Li, Zehao</creatorcontrib><creatorcontrib>Sun, Xing</creatorcontrib><creatorcontrib>Zhao, Zheng</creatorcontrib><title>Photocuring Hyaluronic Acid/Silk Fibroin Hydrogel Containing Curcumin Loaded CHITOSAN Nanoparticles for the Treatment of MG-63 Cells and ME3T3-E1 Cells</title><title>Polymers</title><addtitle>POLYMERS-BASEL</addtitle><description>After an osteosarcoma excision, recurrence and bone defects are significant challenges for clinicians. In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel for the osteosarcoma therapy and bone regeneration was developed by photocuring and ethanol treatment. The micro or nanofibers networks were observed in the CCNPs-SF/HAMA hydrogel. The FTIR results demonstrated that alcohol vapor treatment caused an increase in beta-sheets of SF, resulting in the high compression stress and Young's modulus of CCNPs-SF/HAMA hydrogel. According to the water uptake analysis, SF caused a slight decrease in water uptake of CCNPs-SF/HAMA hydrogel while CCNPs could enhance the water uptake of it. The swelling kinetic results showed that both the CCNPs and the SF increased the swelling ratio of CCNPs-SF/HAMA hydrogel. The accumulative release profile of CCNPs-SF/HAMA hydrogel showed that the release of Cur from CCNPs-SF/HAMA hydrogel was accelerated when pH value was decreased from 7.4 to 5.5. Besides, compared with CCNPs, the CCNPs-SF/HAMA hydrogel had a more sustainable drug release, which was beneficial for the long-term treatment of osteosarcoma. In vitro assay results indicated that CCNPs-SF/HAMA hydrogel with equivalent Cur concentration of 150 mu g/mL possessed both the effect of anti-cancer and promoting the proliferation of osteoblasts. These results suggest that CCNPs-SF/HAMA hydrogel with superior physical properties and the bifunctional osteosarcoma therapy and bone repair may be an excellent candidate for local cancer therapy and bone regeneration.</description><subject>Anticancer properties</subject><subject>Bioavailability</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bone cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Chitosan</subject><subject>Drug delivery systems</subject><subject>Esterification</subject><subject>Ethanol</subject><subject>Extracellular matrix</subject><subject>Hyaluronic acid</subject><subject>Hydrogels</subject><subject>Mechanical properties</subject><subject>Microscopy</subject><subject>Modulus of elasticity</subject><subject>Morphology</subject><subject>Nanofibers</subject><subject>Nanoparticles</subject><subject>Particle size</subject><subject>Physical properties</subject><subject>Physical Sciences</subject><subject>Polymer Science</subject><subject>Regeneration (physiology)</subject><subject>Science & Technology</subject><subject>Silk fibroin</subject><subject>Swelling ratio</subject><subject>Therapy</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNUk1r3DAQNaWlCWmOvQt6KRQnI48t2ZfCYjbZwCYpZHs2sizvKrWlrSS37C_p363MhpD0VF0k5n0wj6ck-UjhArGCy70dDiNFmmcI2ZvkNAOOaY4M3r54nyTn3j9CPHnBGOXvkxPMESgwPE3-fNvZYOXktNmS1UEMk7NGS7KQurt80MMPcqVbZ7WJYOfsVg2ktiYIbWZBPTk5jRFcW9GpjtSrm839w-KO3Alj98IFLQflSW8dCTtFNk6JMCoTiO3J7XXKkNRqGDwRpiO3S9xguqTH0YfkXS8Gr86f7rPk-9VyU6_S9f31Tb1YpzIvypBi39IYhmdStAxAiLZDRoFmvZQ98FIVqm1LULxCxiJcQU5ZBywTgIpmAs-Sr0ff_dSOqpNxOSeGZu_0KNyhsUI3rxGjd83W_mpKhApzFg0-Pxk4-3NSPjSj9jJGEEbZyTdZURQUSsazSP30D_XRTs7EeDMr57yiOBumR5Z01nun-udlKDRz682r1iO_PPJ_q9b2XmplpHrWxNYZ50CrYv4AtNZBBG1NbScTovTL_0vxLyS1vxQ</recordid><startdate>20210714</startdate><enddate>20210714</enddate><creator>Yu, Qingwen</creator><creator>Meng, Zhiyuan</creator><creator>Liu, Yichao</creator><creator>Li, Zehao</creator><creator>Sun, Xing</creator><creator>Zhao, Zheng</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0574-3095</orcidid></search><sort><creationdate>20210714</creationdate><title>Photocuring Hyaluronic Acid/Silk Fibroin Hydrogel Containing Curcumin Loaded CHITOSAN Nanoparticles for the Treatment of MG-63 Cells and ME3T3-E1 Cells</title><author>Yu, Qingwen ; 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In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel for the osteosarcoma therapy and bone regeneration was developed by photocuring and ethanol treatment. The micro or nanofibers networks were observed in the CCNPs-SF/HAMA hydrogel. The FTIR results demonstrated that alcohol vapor treatment caused an increase in beta-sheets of SF, resulting in the high compression stress and Young's modulus of CCNPs-SF/HAMA hydrogel. According to the water uptake analysis, SF caused a slight decrease in water uptake of CCNPs-SF/HAMA hydrogel while CCNPs could enhance the water uptake of it. The swelling kinetic results showed that both the CCNPs and the SF increased the swelling ratio of CCNPs-SF/HAMA hydrogel. The accumulative release profile of CCNPs-SF/HAMA hydrogel showed that the release of Cur from CCNPs-SF/HAMA hydrogel was accelerated when pH value was decreased from 7.4 to 5.5. Besides, compared with CCNPs, the CCNPs-SF/HAMA hydrogel had a more sustainable drug release, which was beneficial for the long-term treatment of osteosarcoma. In vitro assay results indicated that CCNPs-SF/HAMA hydrogel with equivalent Cur concentration of 150 mu g/mL possessed both the effect of anti-cancer and promoting the proliferation of osteoblasts. These results suggest that CCNPs-SF/HAMA hydrogel with superior physical properties and the bifunctional osteosarcoma therapy and bone repair may be an excellent candidate for local cancer therapy and bone regeneration.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>34301063</pmid><doi>10.3390/polym13142302</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-0574-3095</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anticancer properties Bioavailability Biocompatibility Biomedical materials Bone cancer Cancer therapies Chemotherapy Chitosan Drug delivery systems Esterification Ethanol Extracellular matrix Hyaluronic acid Hydrogels Mechanical properties Microscopy Modulus of elasticity Morphology Nanofibers Nanoparticles Particle size Physical properties Physical Sciences Polymer Science Regeneration (physiology) Science & Technology Silk fibroin Swelling ratio Therapy |
| title | Photocuring Hyaluronic Acid/Silk Fibroin Hydrogel Containing Curcumin Loaded CHITOSAN Nanoparticles for the Treatment of MG-63 Cells and ME3T3-E1 Cells |
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