Sub/supercritical Fluid Chromatography Purification and Desalting of a Cyclic Dinucleotide STING Agonist

•An “endotoxin-free” purification and desalting of a cyclic dinucleotide (CDN) was achieved.•The purification and desalting were scaled up to produce multigram quantities of pure target.•Water with buffer additive was essential to improving the peak shape and resolution.•High co-solvent percentage w...

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Veröffentlicht in:	JOURNAL OF CHROMATOGRAPHY A 2021-08, Vol.1652, p.462356, Article 462356
Hauptverfasser:	Li, Peng, Yip, Henry, Sun, Dawn, Kempson, James, Caceres-Cortes, Janet, Mathur, Arvind, Wu, Dauh-Rurng
Format:	Artikel
Sprache:	eng
Schlagworte:	achiral SFC Biochemical Research Methods Biochemistry & Molecular Biology Chemistry Chemistry, Analytical cyclic dinucleotide (CDN) effect of buffer additive effect of water Life Sciences & Biomedicine Physical Sciences Science & Technology STING supercritical fluid chromatography
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